ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MHC class II HLA-DQ-beta-1

Intramolecular
Cysteine 15 and cysteine 79
Cysteine 117 and cysteine 173
A redox-regulated disulphide may form within MHC class II HLA-DQ-beta-1 between cysteines 15 and 79 (51 and 115 respectively in this structure).

Details

Redox score ?
80
PDB code
6mfg
Structure name
hla-dq2-glia-alpha1
Structure deposition date
2018-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
O19712
Residue number A
15
Residue number B
79
Peptide name
MHC class II HLA-DQ-beta-1

Ligandability

Cysteine 15 of MHC class II HLA-DQ-beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of MHC class II HLA-DQ-beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class II HLA-DQ-beta-1 between cysteines 117 and 173.

Details

Redox score ?
79
PDB code
6u3m
Structure name
dq2-p
Structure deposition date
2019-08-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
O19712
Residue number A
117
Residue number B
173
Peptide name
MHC class II HLA-DQ-beta-1

Ligandability

Cysteine 117 of MHC class II HLA-DQ-beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of MHC class II HLA-DQ-beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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