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GDNF family receptor alpha-1

Intramolecular
Cysteine 36 and cysteine 42
Cysteine 182 and cysteine 228
Cysteine 310 and cysteine 320
Cysteine 211 and cysteine 216
Cysteine 272 and cysteine 332
Cysteine 245 and cysteine 251
Cysteine 156 and cysteine 162
Cysteine 149 and cysteine 209
Cysteine 173 and cysteine 187
Cysteine 262 and cysteine 280
More...
Cysteine 238 and cysteine 308
Cysteine 149 and cysteine 211
Cysteine 149 and cysteine 216
Cysteine 187 and cysteine 228
Cysteine 280 and cysteine 332
Cysteine 238 and cysteine 320
Cysteine 238 and cysteine 310
Cysteine 209 and cysteine 211
Cysteine 182 and cysteine 187
Cysteine 173 and cysteine 228
Cysteine 209 and cysteine 216
Cysteine 272 and cysteine 280
Cysteine 262 and cysteine 332
Cysteine 29 and cysteine 99
Cysteine 173 and cysteine 182
Cysteine 308 and cysteine 320
Cysteine 308 and cysteine 310
Cysteine 52 and cysteine 72
Cysteine 262 and cysteine 272
Cysteine 87 and cysteine 89
Cysteine 29 and cysteine 87
Cysteine 29 and cysteine 89
Cysteine 89 and cysteine 99
A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 36 and 42 (17 and 23 respectively in this structure).

Details

Redox score ?
86
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
36
Residue number B
42
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 36 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 42 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 182 and 228 (187 and 233 respectively in this structure).

Details

Redox score ?
86
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
182
Residue number B
228
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 182 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 228 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 310 and 320 (315 and 325 respectively in this structure).

Details

Redox score ?
86
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
310
Residue number B
320
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 310 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 320 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 211 and 216 (216 and 221 respectively in this structure).

Details

Redox score ?
86
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
211
Residue number B
216
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 211 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 272 and 332 (277 and 337 respectively in this structure).

Details

Redox score ?
85
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
272
Residue number B
332
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 272 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 332 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 245 and 251 (250 and 256 respectively in this structure).

Details

Redox score ?
83
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
245
Residue number B
251
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 245 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 251 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 156 and 162 (161 and 167 respectively in this structure).

Details

Redox score ?
83
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
156
Residue number B
162
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 156 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 149 and 209 (154 and 214 respectively in this structure).

Details

Redox score ?
83
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
149
Residue number B
209
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 149 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 209 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 173 and 187 (178 and 192 respectively in this structure).

Details

Redox score ?
83
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
173
Residue number B
187
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 173 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 262 and 280 (267 and 285 respectively in this structure).

Details

Redox score ?
82
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
262
Residue number B
280
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 262 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 238 and 308 (243 and 313 respectively in this structure).

Details

Redox score ?
81
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
238
Residue number B
308
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 238 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 149 and 211 (154 and 216 respectively in this structure).

Details

Redox score ?
78
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
149
Residue number B
211
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 149 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 211 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 149 and 216 (154 and 221 respectively in this structure).

Details

Redox score ?
75
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
149
Residue number B
216
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 149 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 187 and 228 (192 and 233 respectively in this structure).

Details

Redox score ?
75
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
187
Residue number B
228
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 187 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 228 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 280 and 332 (285 and 337 respectively in this structure).

Details

Redox score ?
70
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
280
Residue number B
332
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 280 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 332 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 238 and 320 (243 and 325 respectively in this structure).

Details

Redox score ?
69
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
238
Residue number B
320
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 238 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 320 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 238 and 310 (243 and 315 respectively in this structure).

Details

Redox score ?
69
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
238
Residue number B
310
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 238 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 209 and 211 (214 and 216 respectively in this structure).

Details

Redox score ?
68
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
209
Residue number B
211
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 209 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 211 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 182 and 187 (187 and 192 respectively in this structure).

Details

Redox score ?
67
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
182
Residue number B
187
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 182 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 173 and 228 (178 and 233 respectively in this structure).

Details

Redox score ?
67
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
173
Residue number B
228
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 173 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 228 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 209 and 216 (214 and 221 respectively in this structure).

Details

Redox score ?
64
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
209
Residue number B
216
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 209 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 272 and 280 (277 and 285 respectively in this structure).

Details

Redox score ?
62
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
272
Residue number B
280
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 272 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 262 and 332 (267 and 337 respectively in this structure).

Details

Redox score ?
62
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
262
Residue number B
332
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 262 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 332 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 29 and 99 (10 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
37
Peptide accession
O35748
Residue number A
29
Residue number B
99
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 29 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 173 and 182 (178 and 187 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
173
Residue number B
182
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 173 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 182 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 308 and 320 (313 and 325 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
308
Residue number B
320
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 308 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 320 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 308 and 310 (313 and 315 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
308
Residue number B
310
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 308 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 52 and 72 (33 and 53 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
3
Peptide accession
O35748
Residue number A
52
Residue number B
72
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 52 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 262 and 272 (267 and 277 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O35748
Residue number A
262
Residue number B
272
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 262 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 87 and 89 (68 and 70 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
10
Peptide accession
O35748
Residue number A
87
Residue number B
89
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 87 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 89 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 29 and 87 (10 and 68 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
24
Peptide accession
O35748
Residue number A
29
Residue number B
87
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 29 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 87 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 29 and 89 (10 and 70 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
24
Peptide accession
O35748
Residue number A
29
Residue number B
89
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 29 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 89 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 89 and 99 (70 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4ux8
Structure name
ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
Structure deposition date
2014-08-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
30
Peptide accession
O35748
Residue number A
89
Residue number B
99
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 89 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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