ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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TELO2-interacting protein 1 homolog

Intramolecular
Cysteine 646 and cysteine 682
Cysteine 679 and cysteine 682
A redox-regulated disulphide may form within TELO2-interacting protein 1 homolog between cysteines 646 and 682. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
7f4u
Structure name
cryo-em structure of telo2-tti1-tti2 complex
Structure deposition date
2021-06-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
15
Peptide accession
O43156
Residue number A
646
Residue number B
682
Peptide name
TELO2-interacting protein 1 homolog

Ligandability

Cysteine 646 of TELO2-interacting protein 1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 682 of TELO2-interacting protein 1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TELO2-interacting protein 1 homolog between cysteines 679 and 682. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7f4u
Structure name
cryo-em structure of telo2-tti1-tti2 complex
Structure deposition date
2021-06-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
30
Peptide accession
O43156
Residue number A
679
Residue number B
682
Peptide name
TELO2-interacting protein 1 homolog

Ligandability

Cysteine 679 of TELO2-interacting protein 1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 682 of TELO2-interacting protein 1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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