ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Plexin-B1

Intramolecular
Cysteine 488 and cysteine 533
Cysteine 79 and cysteine 88
Cysteine 502 and cysteine 514
Cysteine 482 and cysteine 499
Cysteine 491 and cysteine 508
Cysteine 340 and cysteine 364
Cysteine 252 and cysteine 377
Cysteine 268 and cysteine 322
Cysteine 111 and cysteine 119
Cysteine 482 and cysteine 508
More...
Cysteine 499 and cysteine 508
Cysteine 482 and cysteine 491
Cysteine 491 and cysteine 499
Cysteine 488 and cysteine 491
Cysteine 491 and cysteine 533
Cysteine 488 and cysteine 508
Cysteine 508 and cysteine 533
Cysteine 491 and cysteine 514
Cysteine 491 and cysteine 502
Cysteine 502 and cysteine 508
A redox-regulated disulphide may form within Plexin-B1 between cysteines 488 and 533.

Details

Redox score ?
88
PDB code
7vf3
Structure name
plexin b1 extracellular fragment in complex with lasso-grafted pb1m7 peptide
Structure deposition date
2021-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
488
Residue number B
533
Peptide name
Plexin-B1

Ligandability

Cysteine 488 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 533 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 79 and 88.

Details

Redox score ?
86
PDB code
3ol2
Structure name
receptor-ligand structure of human semaphorin 4d with plexin b1
Structure deposition date
2010-08-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
79
Residue number B
88
Peptide name
Plexin-B1

Ligandability

Cysteine 79 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 502 and 514.

Details

Redox score ?
85
PDB code
7vf3
Structure name
plexin b1 extracellular fragment in complex with lasso-grafted pb1m7 peptide
Structure deposition date
2021-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
502
Residue number B
514
Peptide name
Plexin-B1

Ligandability

Cysteine 502 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 514 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 482 and 499.

Details

Redox score ?
85
PDB code
7vf3
Structure name
plexin b1 extracellular fragment in complex with lasso-grafted pb1m7 peptide
Structure deposition date
2021-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
482
Residue number B
499
Peptide name
Plexin-B1

Ligandability

Cysteine 482 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 499 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 491 and 508.

Details

Redox score ?
84
PDB code
7vg7
Structure name
plexin b1 extracellular fragment in complex with lasso-grafted pb1m6a9 peptide
Structure deposition date
2021-09-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
491
Residue number B
508
Peptide name
Plexin-B1

Ligandability

Cysteine 491 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 508 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 340 and 364.

Details

Redox score ?
84
PDB code
5b4w
Structure name
crystal structure of plexin inhibitor complex
Structure deposition date
2016-04-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
340
Residue number B
364
Peptide name
Plexin-B1

Ligandability

Cysteine 340 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 364 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 252 and 377.

Details

Redox score ?
80
PDB code
7vg7
Structure name
plexin b1 extracellular fragment in complex with lasso-grafted pb1m6a9 peptide
Structure deposition date
2021-09-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
252
Residue number B
377
Peptide name
Plexin-B1

Ligandability

Cysteine 252 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 377 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 268 and 322.

Details

Redox score ?
79
PDB code
5b4w
Structure name
crystal structure of plexin inhibitor complex
Structure deposition date
2016-04-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
268
Residue number B
322
Peptide name
Plexin-B1

Ligandability

Cysteine 268 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 111 and 119.

Details

Redox score ?
78
PDB code
5b4w
Structure name
crystal structure of plexin inhibitor complex
Structure deposition date
2016-04-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
111
Residue number B
119
Peptide name
Plexin-B1

Ligandability

Cysteine 111 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 119 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 482 and 508.

Details

Redox score ?
69
PDB code
3ol2
Structure name
receptor-ligand structure of human semaphorin 4d with plexin b1
Structure deposition date
2010-08-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
482
Residue number B
508
Peptide name
Plexin-B1

Ligandability

Cysteine 482 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 508 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 499 and 508.

Details

Redox score ?
66
PDB code
5b4w
Structure name
crystal structure of plexin inhibitor complex
Structure deposition date
2016-04-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
499
Residue number B
508
Peptide name
Plexin-B1

Ligandability

Cysteine 499 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 508 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 482 and 491.

Details

Redox score ?
61
PDB code
7vf3
Structure name
plexin b1 extracellular fragment in complex with lasso-grafted pb1m7 peptide
Structure deposition date
2021-09-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
482
Residue number B
491
Peptide name
Plexin-B1

Ligandability

Cysteine 482 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 491 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 491 and 499.

Details

Redox score ?
60
PDB code
3ol2
Structure name
receptor-ligand structure of human semaphorin 4d with plexin b1
Structure deposition date
2010-08-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
491
Residue number B
499
Peptide name
Plexin-B1

Ligandability

Cysteine 491 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 499 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 488 and 491.

Details

Redox score ?
60
PDB code
7vf3
Structure name
plexin b1 extracellular fragment in complex with lasso-grafted pb1m7 peptide
Structure deposition date
2021-09-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
488
Residue number B
491
Peptide name
Plexin-B1

Ligandability

Cysteine 488 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 491 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 491 and 533. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
3ol2
Structure name
receptor-ligand structure of human semaphorin 4d with plexin b1
Structure deposition date
2010-08-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
491
Residue number B
533
Peptide name
Plexin-B1

Ligandability

Cysteine 491 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 533 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 488 and 508. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5b4w
Structure name
crystal structure of plexin inhibitor complex
Structure deposition date
2016-04-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
nan
Peptide accession
O43157
Residue number A
488
Residue number B
508
Peptide name
Plexin-B1

Ligandability

Cysteine 488 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 508 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 508 and 533. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3ol2
Structure name
receptor-ligand structure of human semaphorin 4d with plexin b1
Structure deposition date
2010-08-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
508
Residue number B
533
Peptide name
Plexin-B1

Ligandability

Cysteine 508 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 533 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 491 and 514. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3ol2
Structure name
receptor-ligand structure of human semaphorin 4d with plexin b1
Structure deposition date
2010-08-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
491
Residue number B
514
Peptide name
Plexin-B1

Ligandability

Cysteine 491 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 514 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 491 and 502. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7vf3
Structure name
plexin b1 extracellular fragment in complex with lasso-grafted pb1m7 peptide
Structure deposition date
2021-09-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
491
Residue number B
502
Peptide name
Plexin-B1

Ligandability

Cysteine 491 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 502 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B1 between cysteines 502 and 508. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7vg7
Structure name
plexin b1 extracellular fragment in complex with lasso-grafted pb1m6a9 peptide
Structure deposition date
2021-09-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43157
Residue number A
502
Residue number B
508
Peptide name
Plexin-B1

Ligandability

Cysteine 502 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 508 of Plexin-B1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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