ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc finger and BTB domain-containing protein 24

Intramolecular
Cysteine 407 and cysteine 410
Cysteine 463 and cysteine 466
Cysteine 491 and cysteine 494
Cysteine 463 and cysteine 480
Cysteine 435 and cysteine 438
Cysteine 379 and cysteine 382
Cysteine 466 and cysteine 480
Cysteine 466 and cysteine 469
A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 24 between cysteines 407 and 410.

Details

Redox score ?
90
PDB code
6ml6
Structure name
zbtb24 zinc fingers 4-8 with 19+1mer dna oligonucleotide (sequence 4 with a cpa 5mc modification)
Structure deposition date
2018-09-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
5
% buried
0
Peptide accession
Q80X44
Residue number A
407
Residue number B
410
Peptide name
Zinc finger and BTB domain-containing protein 24

Ligandability

Cysteine 407 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 410 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 24 between cysteines 463 and 466.

Details

Redox score ?
89
PDB code
6ml7
Structure name
zbtb24 zinc fingers 4-8 with 19+1mer dna oligonucleotide (sequence 4 with a cpg 5mc modification)
Structure deposition date
2018-09-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
5
% buried
0
Peptide accession
Q80X44
Residue number A
463
Residue number B
466
Peptide name
Zinc finger and BTB domain-containing protein 24

Ligandability

Cysteine 463 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 466 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 24 between cysteines 491 and 494.

Details

Redox score ?
89
PDB code
6ml7
Structure name
zbtb24 zinc fingers 4-8 with 19+1mer dna oligonucleotide (sequence 4 with a cpg 5mc modification)
Structure deposition date
2018-09-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
6
% buried
0
Peptide accession
Q80X44
Residue number A
491
Residue number B
494
Peptide name
Zinc finger and BTB domain-containing protein 24

Ligandability

Cysteine 491 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 494 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 24 between cysteines 463 and 480.

Details

Redox score ?
89
PDB code
6ml7
Structure name
zbtb24 zinc fingers 4-8 with 19+1mer dna oligonucleotide (sequence 4 with a cpg 5mc modification)
Structure deposition date
2018-09-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
5
% buried
6
Peptide accession
Q80X44
Residue number A
463
Residue number B
480
Peptide name
Zinc finger and BTB domain-containing protein 24

Ligandability

Cysteine 463 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 480 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 24 between cysteines 435 and 438.

Details

Redox score ?
88
PDB code
6ml5
Structure name
zbtb24 zinc fingers 4-8 with 19+1mer dna oligonucleotide (sequence 4)
Structure deposition date
2018-09-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
6
% buried
0
Peptide accession
Q80X44
Residue number A
435
Residue number B
438
Peptide name
Zinc finger and BTB domain-containing protein 24

Ligandability

Cysteine 435 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 438 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 24 between cysteines 379 and 382.

Details

Redox score ?
86
PDB code
6ml4
Structure name
btb24 zinc fingers 4-8 with 19+1mer dna oligonucleotide (sequence 3)
Structure deposition date
2018-09-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
7
% buried
0
Peptide accession
Q80X44
Residue number A
379
Residue number B
382
Peptide name
Zinc finger and BTB domain-containing protein 24

Ligandability

Cysteine 379 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 24 between cysteines 466 and 480.

Details

Redox score ?
62
PDB code
6ml5
Structure name
zbtb24 zinc fingers 4-8 with 19+1mer dna oligonucleotide (sequence 4)
Structure deposition date
2018-09-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
36
Minimum pKa ?
8
% buried
6
Peptide accession
Q80X44
Residue number A
466
Residue number B
480
Peptide name
Zinc finger and BTB domain-containing protein 24

Ligandability

Cysteine 466 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 480 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger and BTB domain-containing protein 24 between cysteines 466 and 469. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
6ml2
Structure name
zbtb24 zinc fingers 4-8 with 19+1mer dna oligonucleotide (sequence 1)
Structure deposition date
2018-09-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
35
Minimum pKa ?
8
% buried
0
Peptide accession
Q80X44
Residue number A
466
Residue number B
469
Peptide name
Zinc finger and BTB domain-containing protein 24

Ligandability

Cysteine 466 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 469 of Zinc finger and BTB domain-containing protein 24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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