ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytoplasmic dynein 1 light intermediate chain 2

Intramolecular
Cysteine 231 and cysteine 234
Cysteine 231 and cysteine 262
A redox-regulated disulphide may form within Cytoplasmic dynein 1 light intermediate chain 2 between cysteines 231 and 234. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
6f1t
Structure name
cryo-em structure of two dynein tail domains bound to dynactin and bicdr1
Structure deposition date
2017-11-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
97
Peptide accession
O43237
Residue number A
231
Residue number B
234
Peptide name
Cytoplasmic dynein 1 light intermediate chain 2

Ligandability

Cysteine 231 of Cytoplasmic dynein 1 light intermediate chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 234 of Cytoplasmic dynein 1 light intermediate chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytoplasmic dynein 1 light intermediate chain 2 between cysteines 231 and 262. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6f1t
Structure name
cryo-em structure of two dynein tail domains bound to dynactin and bicdr1
Structure deposition date
2017-11-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
88
Minimum pKa ?
13
% buried
100
Peptide accession
O43237
Residue number A
231
Residue number B
262
Peptide name
Cytoplasmic dynein 1 light intermediate chain 2

Ligandability

Cysteine 231 of Cytoplasmic dynein 1 light intermediate chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 262 of Cytoplasmic dynein 1 light intermediate chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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