ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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E3 ubiquitin-protein ligase SIAH2

Intramolecular
Cysteine 138 and cysteine 145
Cysteine 168 and cysteine 175
Cysteine 145 and cysteine 161
Cysteine 138 and cysteine 161
Cysteine 168 and cysteine 170
Cysteine 170 and cysteine 175
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase SIAH2 between cysteines 138 and 145.

Details

Redox score ?
79
PDB code
5h9m
Structure name
crystal structure of siah2 sbd domain
Structure deposition date
2015-12-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43255
Residue number A
138
Residue number B
145
Peptide name
E3 ubiquitin-protein ligase SIAH2

Ligandability

Cysteine 138 of E3 ubiquitin-protein ligase SIAH2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of E3 ubiquitin-protein ligase SIAH2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase SIAH2 between cysteines 168 and 175.

Details

Redox score ?
78
PDB code
5h9m
Structure name
crystal structure of siah2 sbd domain
Structure deposition date
2015-12-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43255
Residue number A
168
Residue number B
175
Peptide name
E3 ubiquitin-protein ligase SIAH2

Ligandability

Cysteine 168 of E3 ubiquitin-protein ligase SIAH2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 175 of E3 ubiquitin-protein ligase SIAH2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase SIAH2 between cysteines 145 and 161.

Details

Redox score ?
77
PDB code
5h9m
Structure name
crystal structure of siah2 sbd domain
Structure deposition date
2015-12-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43255
Residue number A
145
Residue number B
161
Peptide name
E3 ubiquitin-protein ligase SIAH2

Ligandability

Cysteine 145 of E3 ubiquitin-protein ligase SIAH2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 161 of E3 ubiquitin-protein ligase SIAH2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase SIAH2 between cysteines 138 and 161.

Details

Redox score ?
75
PDB code
5h9m
Structure name
crystal structure of siah2 sbd domain
Structure deposition date
2015-12-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43255
Residue number A
138
Residue number B
161
Peptide name
E3 ubiquitin-protein ligase SIAH2

Ligandability

Cysteine 138 of E3 ubiquitin-protein ligase SIAH2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 161 of E3 ubiquitin-protein ligase SIAH2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase SIAH2 between cysteines 168 and 170.

Details

Redox score ?
62
PDB code
5h9m
Structure name
crystal structure of siah2 sbd domain
Structure deposition date
2015-12-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43255
Residue number A
168
Residue number B
170
Peptide name
E3 ubiquitin-protein ligase SIAH2

Ligandability

Cysteine 168 of E3 ubiquitin-protein ligase SIAH2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 170 of E3 ubiquitin-protein ligase SIAH2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase SIAH2 between cysteines 170 and 175. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
5h9m
Structure name
crystal structure of siah2 sbd domain
Structure deposition date
2015-12-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43255
Residue number A
170
Residue number B
175
Peptide name
E3 ubiquitin-protein ligase SIAH2

Ligandability

Cysteine 170 of E3 ubiquitin-protein ligase SIAH2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 175 of E3 ubiquitin-protein ligase SIAH2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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