ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Centromere/kinetochore protein zw10 homolog

Intramolecular
Cysteine 545 and cysteine 588
Cysteine 39 and cysteine 153
Cysteine 404 and cysteine 504
Cysteine 341 and cysteine 346 L
A redox-regulated disulphide may form within Centromere/kinetochore protein zw10 homolog between cysteines 545 and 588. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7qpg
Structure name
human rzz kinetochore corona complex
Structure deposition date
2022-01-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
88
Peptide accession
O43264
Residue number A
545
Residue number B
588
Peptide name
Centromere/kinetochore protein zw10 homolog

Ligandability

Cysteine 545 of Centromere/kinetochore protein zw10 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 588 of Centromere/kinetochore protein zw10 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centromere/kinetochore protein zw10 homolog between cysteines 39 and 153. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7qpg
Structure name
human rzz kinetochore corona complex
Structure deposition date
2022-01-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
21
Peptide accession
O43264
Residue number A
39
Residue number B
153
Peptide name
Centromere/kinetochore protein zw10 homolog

Ligandability

Cysteine 39 of Centromere/kinetochore protein zw10 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 153 of Centromere/kinetochore protein zw10 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centromere/kinetochore protein zw10 homolog between cysteines 404 and 504. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7qpg
Structure name
human rzz kinetochore corona complex
Structure deposition date
2022-01-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
9
% buried
80
Peptide accession
O43264
Residue number A
404
Residue number B
504
Peptide name
Centromere/kinetochore protein zw10 homolog

Ligandability

Cysteine 404 of Centromere/kinetochore protein zw10 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 504 of Centromere/kinetochore protein zw10 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centromere/kinetochore protein zw10 homolog between cysteines 341 and 346. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7qpg
Structure name
human rzz kinetochore corona complex
Structure deposition date
2022-01-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
70
Peptide accession
O43264
Residue number A
341
Residue number B
346
Peptide name
Centromere/kinetochore protein zw10 homolog

Ligandability

Cysteine 341 of Centromere/kinetochore protein zw10 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 346 of Centromere/kinetochore protein zw10 homolog

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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