a tool for identifying drug-targetable redox-active disulphides

Glycosylphosphatidylinositol anchor attachment 1 protein

Intramolecular

Cysteine 259 and cysteine 266

A redox-regulated disulphide may form within Glycosylphosphatidylinositol anchor attachment 1 protein between cysteines 259 and 266.

Details

Redox score ?

84

PDB code

Structure name

cryo-em structure of the human glycosylphosphatidylinositol transamidase complex at 2

Structure deposition date

2022-01-13

Thiol separation (Å)

2

Half-sphere exposure sum ?

64

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

259

Residue number B

266

Peptide name

Glycosylphosphatidylinositol anchor attachment 1 protein

Ligandability

Cysteine 259 of Glycosylphosphatidylinositol anchor attachment 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 266 of Glycosylphosphatidylinositol anchor attachment 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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