Mitogen-activated protein kinase kinase kinase 7
Intramolecular
Cysteine 96 and cysteine 101
Cysteine 134 and cysteine 137
Cysteine 51 and cysteine 101
Cysteine 134 and cysteine 266
2eva A 96 A 101
A redox-regulated disulphide may form within Mitogen-activated protein kinase kinase kinase 7 between cysteines 96 and 101.
Details
Redox score ?
73
PDB code
2eva
Structure name
structural basis for the interaction of tak1 kinase with its activating protein tab1
Structure deposition date
2005-10-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
58
Peptide accession
O43318
Residue number A
96
Residue number B
101
Peptide name
Mitogen-activated protein kinase kinase kinase 7
Ligandability
Cysteine 96 of Mitogen-activated protein kinase kinase kinase 7
Cysteine 101 of Mitogen-activated protein kinase kinase kinase 7
2eva A 134 A 137
A redox-regulated disulphide may form within Mitogen-activated protein kinase kinase kinase 7 between cysteines 134 and 137. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
2eva
Structure name
structural basis for the interaction of tak1 kinase with its activating protein tab1
Structure deposition date
2005-10-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
92
Minimum pKa ?
12
% buried
100
Peptide accession
O43318
Residue number A
134
Residue number B
137
Peptide name
Mitogen-activated protein kinase kinase kinase 7
Ligandability
Cysteine 134 of Mitogen-activated protein kinase kinase kinase 7
Cysteine 137 of Mitogen-activated protein kinase kinase kinase 7
2eva A 51 A 101
A redox-regulated disulphide may form within Mitogen-activated protein kinase kinase kinase 7 between cysteines 51 and 101. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
2eva
Structure name
structural basis for the interaction of tak1 kinase with its activating protein tab1
Structure deposition date
2005-10-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
51
Peptide accession
O43318
Residue number A
51
Residue number B
101
Peptide name
Mitogen-activated protein kinase kinase kinase 7
Ligandability
Cysteine 51 of Mitogen-activated protein kinase kinase kinase 7
Cysteine 101 of Mitogen-activated protein kinase kinase kinase 7
2eva A 134 A 266
A redox-regulated disulphide may form within Mitogen-activated protein kinase kinase kinase 7 between cysteines 134 and 266. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
24
PDB code
2eva
Structure name
structural basis for the interaction of tak1 kinase with its activating protein tab1
Structure deposition date
2005-10-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
100
Peptide accession
O43318
Residue number A
134
Residue number B
266
Peptide name
Mitogen-activated protein kinase kinase kinase 7
Ligandability
Cysteine 134 of Mitogen-activated protein kinase kinase kinase 7
Cysteine 266 of Mitogen-activated protein kinase kinase kinase 7
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