ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Synaptojanin-1

Intramolecular
Cysteine 687 and cysteine 728
Cysteine 637 and cysteine 687
A redox-regulated disulphide may form within Synaptojanin-1 between cysteines 687 and 728.

Details

Redox score ?
61
PDB code
7a0v
Structure name
crystal structure of the 5-phosphatase domain of synaptojanin1 in complex with a nanobody
Structure deposition date
2020-08-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
102
Minimum pKa ?
9
% buried
100
Peptide accession
O43426
Residue number A
687
Residue number B
728
Peptide name
Synaptojanin-1

Ligandability

Cysteine 687 of Synaptojanin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 728 of Synaptojanin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Synaptojanin-1 between cysteines 637 and 687. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
7a17
Structure name
crystal structure of the 5-phosphatase domain of synaptojanin1 bound to its substrate dic8-pi(3,4,5)p3 in complex with a nanobody
Structure deposition date
2020-08-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
106
Minimum pKa ?
13
% buried
98
Peptide accession
O43426
Residue number A
637
Residue number B
687
Peptide name
Synaptojanin-1

Ligandability

Cysteine 637 of Synaptojanin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 687 of Synaptojanin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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