ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Eukaryotic translation initiation factor 4 gamma 3

Intramolecular
Cysteine 813 and cysteine 841
Cysteine 813 and cysteine 815
Cysteine 913 and cysteine 928
Cysteine 841 and cysteine 913
Cysteine 928 and cysteine 930
A redox-regulated disulphide may form within Eukaryotic translation initiation factor 4 gamma 3 between cysteines 813 and 841. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1hu3
Structure name
middle domain of human eif4gii
Structure deposition date
2001-01-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
12
% buried
94
Peptide accession
O43432
Residue number A
813
Residue number B
841
Peptide name
Eukaryotic translation initiation factor 4 gamma 3

Ligandability

Cysteine 813 of Eukaryotic translation initiation factor 4 gamma 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 841 of Eukaryotic translation initiation factor 4 gamma 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Eukaryotic translation initiation factor 4 gamma 3 between cysteines 813 and 815. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1hu3
Structure name
middle domain of human eif4gii
Structure deposition date
2001-01-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
11
% buried
68
Peptide accession
O43432
Residue number A
813
Residue number B
815
Peptide name
Eukaryotic translation initiation factor 4 gamma 3

Ligandability

Cysteine 813 of Eukaryotic translation initiation factor 4 gamma 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 815 of Eukaryotic translation initiation factor 4 gamma 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Eukaryotic translation initiation factor 4 gamma 3 between cysteines 913 and 928. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1hu3
Structure name
middle domain of human eif4gii
Structure deposition date
2001-01-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
86
Peptide accession
O43432
Residue number A
913
Residue number B
928
Peptide name
Eukaryotic translation initiation factor 4 gamma 3

Ligandability

Cysteine 913 of Eukaryotic translation initiation factor 4 gamma 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 928 of Eukaryotic translation initiation factor 4 gamma 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Eukaryotic translation initiation factor 4 gamma 3 between cysteines 841 and 913. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1hu3
Structure name
middle domain of human eif4gii
Structure deposition date
2001-01-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
91
Peptide accession
O43432
Residue number A
841
Residue number B
913
Peptide name
Eukaryotic translation initiation factor 4 gamma 3

Ligandability

Cysteine 841 of Eukaryotic translation initiation factor 4 gamma 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 913 of Eukaryotic translation initiation factor 4 gamma 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Eukaryotic translation initiation factor 4 gamma 3 between cysteines 928 and 930. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
1hu3
Structure name
middle domain of human eif4gii
Structure deposition date
2001-01-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
72
Peptide accession
O43432
Residue number A
928
Residue number B
930
Peptide name
Eukaryotic translation initiation factor 4 gamma 3

Ligandability

Cysteine 928 of Eukaryotic translation initiation factor 4 gamma 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 930 of Eukaryotic translation initiation factor 4 gamma 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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