ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Peptidyl-prolyl cis-trans isomerase H

Intramolecular
Cysteine 47 and cysteine 174
Cysteine 128 and cysteine 131
A redox-regulated disulphide may form within Peptidyl-prolyl cis-trans isomerase H between cysteines 47 and 174.

Details

Redox score ?
62
PDB code
1qoi
Structure name
u4/u6 snrnp-specific cyclophilin snucyp-20
Structure deposition date
1999-11-09
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
84
Peptide accession
O43447
Residue number A
47
Residue number B
174
Peptide name
Peptidyl-prolyl cis-trans isomerase H

Ligandability

Cysteine 47 of Peptidyl-prolyl cis-trans isomerase H

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Peptidyl-prolyl cis-trans isomerase H

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptidyl-prolyl cis-trans isomerase H between cysteines 128 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1qoi
Structure name
u4/u6 snrnp-specific cyclophilin snucyp-20
Structure deposition date
1999-11-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
11
% buried
50
Peptide accession
O43447
Residue number A
128
Residue number B
131
Peptide name
Peptidyl-prolyl cis-trans isomerase H

Ligandability

Cysteine 128 of Peptidyl-prolyl cis-trans isomerase H

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 131 of Peptidyl-prolyl cis-trans isomerase H

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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