ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Maltase-glucoamylase

Intramolecular
Cysteine 978 and cysteine 996
Cysteine 101 and cysteine 117
Cysteine 966 and cysteine 983
Cysteine 1436 and cysteine 1463
Cysteine 544 and cysteine 569
Cysteine 112 and cysteine 130
Cysteine 1557 and cysteine 1568
Cysteine 659 and cysteine 670
Cysteine 966 and cysteine 996
Cysteine 983 and cysteine 996
More...
Cysteine 978 and cysteine 983
Cysteine 966 and cysteine 978
Cysteine 112 and cysteine 117
Cysteine 101 and cysteine 130
Cysteine 117 and cysteine 130
Cysteine 101 and cysteine 112
Cysteine 112 and cysteine 118
Cysteine 117 and cysteine 118
Cysteine 118 and cysteine 130
Cysteine 101 and cysteine 118
Cysteine 544 and cysteine 565
A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 978 and 996.

Details

Redox score ?
86
PDB code
3ton
Structure name
crystral structure of the c-terminal subunit of human maltase- glucoamylase
Structure deposition date
2011-09-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43451
Residue number A
978
Residue number B
996
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 978 of Maltase-glucoamylase

Cysteine 996 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 101 and 117 (15 and 31 respectively in this structure).

Details

Redox score ?
85
PDB code
3l4z
Structure name
crystal complex of n-terminal human maltase-glucoamylase with salacinol
Structure deposition date
2009-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43451
Residue number A
101
Residue number B
117
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 101 of Maltase-glucoamylase

Cysteine 117 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 966 and 983.

Details

Redox score ?
85
PDB code
3top
Structure name
crystral structure of the c-terminal subunit of human maltase- glucoamylase in complex with acarbose
Structure deposition date
2011-09-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43451
Residue number A
966
Residue number B
983
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 966 of Maltase-glucoamylase

Cysteine 983 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 1436 and 1463.

Details

Redox score ?
84
PDB code
3ton
Structure name
crystral structure of the c-terminal subunit of human maltase- glucoamylase
Structure deposition date
2011-09-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43451
Residue number A
1436
Residue number B
1463
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 1436 of Maltase-glucoamylase

Cysteine 1463 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 544 and 569 (458 and 483 respectively in this structure).

Details

Redox score ?
83
PDB code
3l4w
Structure name
crystal complex of n-terminal human maltase-glucoamylase with miglitol
Structure deposition date
2009-12-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
58
Peptide accession
O43451
Residue number A
544
Residue number B
569
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 544 of Maltase-glucoamylase

Cysteine 569 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 112 and 130 (26 and 44 respectively in this structure).

Details

Redox score ?
82
PDB code
3l4u
Structure name
crystal complex of n-terminal human maltase-glucoamylase with de-o- sulfonated kotalanol
Structure deposition date
2009-12-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
34
Peptide accession
O43451
Residue number A
112
Residue number B
130
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 112 of Maltase-glucoamylase

Cysteine 130 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 1557 and 1568.

Details

Redox score ?
77
PDB code
3ton
Structure name
crystral structure of the c-terminal subunit of human maltase- glucoamylase
Structure deposition date
2011-09-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43451
Residue number A
1557
Residue number B
1568
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 1557 of Maltase-glucoamylase

Cysteine 1568 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 659 and 670 (573 and 584 respectively in this structure).

Details

Redox score ?
77
PDB code
3l4u
Structure name
crystal complex of n-terminal human maltase-glucoamylase with de-o- sulfonated kotalanol
Structure deposition date
2009-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
97
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43451
Residue number A
659
Residue number B
670
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 659 of Maltase-glucoamylase

Cysteine 670 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 966 and 996.

Details

Redox score ?
72
PDB code
3ton
Structure name
crystral structure of the c-terminal subunit of human maltase- glucoamylase
Structure deposition date
2011-09-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43451
Residue number A
966
Residue number B
996
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 966 of Maltase-glucoamylase

Cysteine 996 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 983 and 996.

Details

Redox score ?
72
PDB code
3top
Structure name
crystral structure of the c-terminal subunit of human maltase- glucoamylase in complex with acarbose
Structure deposition date
2011-09-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43451
Residue number A
983
Residue number B
996
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 983 of Maltase-glucoamylase

Cysteine 996 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 978 and 983.

Details

Redox score ?
70
PDB code
3ton
Structure name
crystral structure of the c-terminal subunit of human maltase- glucoamylase
Structure deposition date
2011-09-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43451
Residue number A
978
Residue number B
983
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 978 of Maltase-glucoamylase

Cysteine 983 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 966 and 978.

Details

Redox score ?
68
PDB code
3ton
Structure name
crystral structure of the c-terminal subunit of human maltase- glucoamylase
Structure deposition date
2011-09-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43451
Residue number A
966
Residue number B
978
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 966 of Maltase-glucoamylase

Cysteine 978 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 112 and 117 (26 and 31 respectively in this structure).

Details

Redox score ?
66
PDB code
3ctt
Structure name
crystal complex of n-terminal human maltase-glucoamylase with casuarine
Structure deposition date
2008-04-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
nan
Peptide accession
O43451
Residue number A
112
Residue number B
117
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 112 of Maltase-glucoamylase

Cysteine 117 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 101 and 130 (15 and 44 respectively in this structure).

Details

Redox score ?
65
PDB code
3l4y
Structure name
crystal complex of n-terminal human maltase-glucoamylase with nr4-8ii
Structure deposition date
2009-12-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
13
% buried
nan
Peptide accession
O43451
Residue number A
101
Residue number B
130
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 101 of Maltase-glucoamylase

Cysteine 130 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 117 and 130 (31 and 44 respectively in this structure).

Details

Redox score ?
64
PDB code
3l4u
Structure name
crystal complex of n-terminal human maltase-glucoamylase with de-o- sulfonated kotalanol
Structure deposition date
2009-12-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
13
% buried
nan
Peptide accession
O43451
Residue number A
117
Residue number B
130
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 117 of Maltase-glucoamylase

Cysteine 130 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 101 and 112 (15 and 26 respectively in this structure).

Details

Redox score ?
61
PDB code
3ctt
Structure name
crystal complex of n-terminal human maltase-glucoamylase with casuarine
Structure deposition date
2008-04-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
nan
Peptide accession
O43451
Residue number A
101
Residue number B
112
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 101 of Maltase-glucoamylase

Cysteine 112 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 112 and 118 (26 and 32 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
3l4t
Structure name
crystal complex of n-terminal human maltase-glucoamylase with bj2661
Structure deposition date
2009-12-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
16
Peptide accession
O43451
Residue number A
112
Residue number B
118
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 112 of Maltase-glucoamylase

Cysteine 118 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 117 and 118 (31 and 32 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
3l4t
Structure name
crystal complex of n-terminal human maltase-glucoamylase with bj2661
Structure deposition date
2009-12-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
nan
Peptide accession
O43451
Residue number A
117
Residue number B
118
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 117 of Maltase-glucoamylase

Cysteine 118 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 118 and 130 (32 and 44 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
3l4t
Structure name
crystal complex of n-terminal human maltase-glucoamylase with bj2661
Structure deposition date
2009-12-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
28
Peptide accession
O43451
Residue number A
118
Residue number B
130
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 118 of Maltase-glucoamylase

Cysteine 130 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 101 and 118 (15 and 32 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3l4v
Structure name
crystal complex of n-terminal human maltase-glucoamylase with kotalanol
Structure deposition date
2009-12-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
nan
Peptide accession
O43451
Residue number A
101
Residue number B
118
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 101 of Maltase-glucoamylase

Cysteine 118 of Maltase-glucoamylase

A redox-regulated disulphide may form within Maltase-glucoamylase between cysteines 544 and 565 (458 and 479 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3ctt
Structure name
crystal complex of n-terminal human maltase-glucoamylase with casuarine
Structure deposition date
2008-04-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
48
Peptide accession
O43451
Residue number A
544
Residue number B
565
Peptide name
Maltase-glucoamylase

Ligandability

Cysteine 544 of Maltase-glucoamylase

Cysteine 565 of Maltase-glucoamylase

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