ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Krueppel-like factor 4

Intramolecular
Cysteine 402 and cysteine 407 L
Cysteine 432 and cysteine 437
Cysteine 462 and cysteine 465
A redox-regulated disulphide may form within Krueppel-like factor 4 between cysteines 402 and 407.

Details

Redox score ?
91
PDB code
5ke9
Structure name
mouse klf4 e446p znf1-3 and tpg/cpa sequence dna complex structure
Structure deposition date
2016-06-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
38
Minimum pKa ?
7
% buried
0
Peptide accession
Q60793
Residue number A
402
Residue number B
407
Peptide name
Krueppel-like factor 4

Ligandability

Cysteine 402 of Krueppel-like factor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 407 of Krueppel-like factor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Krueppel-like factor 4 between cysteines 432 and 437.

Details

Redox score ?
89
PDB code
5keb
Structure name
mouse klf4 znf1-3 (e446d) and cpg/cpg sequence dna complex structure: form ii
Structure deposition date
2016-06-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
8
% buried
0
Peptide accession
Q60793
Residue number A
432
Residue number B
437
Peptide name
Krueppel-like factor 4

Ligandability

Cysteine 432 of Krueppel-like factor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 437 of Krueppel-like factor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Krueppel-like factor 4 between cysteines 462 and 465.

Details

Redox score ?
88
PDB code
2wbu
Structure name
crystal structure of the zinc finger domain of klf4 bound to its target dna
Structure deposition date
2009-03-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
7
% buried
0
Peptide accession
Q60793
Residue number A
462
Residue number B
465
Peptide name
Krueppel-like factor 4

Ligandability

Cysteine 462 of Krueppel-like factor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 465 of Krueppel-like factor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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