ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Voltage-dependent T-type calcium channel subunit alpha-1G

Intramolecular
Cysteine 1770 and cysteine 1776
Cysteine 1441 and cysteine 1455
Cysteine 104 and cysteine 889
Cysteine 271 and cysteine 282
Cysteine 282 and cysteine 323
Cysteine 241 and cysteine 271
Cysteine 271 and cysteine 323
Cysteine 241 and cysteine 282
Cysteine 1419 and cysteine 1420
Cysteine 241 and cysteine 323
Cysteine 218 and cysteine 390
A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1G between cysteines 1770 and 1776 (1747 and 1753 respectively in this structure).

Details

Redox score ?
89
PDB code
6kzo
Structure name
membrane protein
Structure deposition date
2019-09-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43497
Residue number A
1770
Residue number B
1776
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1G

Ligandability

Cysteine 1770 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1776 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1G between cysteines 1441 and 1455 (1418 and 1432 respectively in this structure).

Details

Redox score ?
87
PDB code
6kzo
Structure name
membrane protein
Structure deposition date
2019-09-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43497
Residue number A
1441
Residue number B
1455
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1G

Ligandability

Cysteine 1441 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1455 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1G between cysteines 104 and 889.

Details

Redox score ?
71
PDB code
6kzp
Structure name
calcium channel-ligand
Structure deposition date
2019-09-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
10
Peptide accession
O43497
Residue number A
104
Residue number B
889
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1G

Ligandability

Cysteine 104 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 889 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1G between cysteines 271 and 282.

Details

Redox score ?
70
PDB code
6kzp
Structure name
calcium channel-ligand
Structure deposition date
2019-09-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43497
Residue number A
271
Residue number B
282
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1G

Ligandability

Cysteine 271 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 282 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1G between cysteines 282 and 323.

Details

Redox score ?
70
PDB code
6kzp
Structure name
calcium channel-ligand
Structure deposition date
2019-09-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43497
Residue number A
282
Residue number B
323
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1G

Ligandability

Cysteine 282 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1G between cysteines 241 and 271.

Details

Redox score ?
67
PDB code
6kzo
Structure name
membrane protein
Structure deposition date
2019-09-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
nan
Peptide accession
O43497
Residue number A
241
Residue number B
271
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1G

Ligandability

Cysteine 241 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 271 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1G between cysteines 271 and 323.

Details

Redox score ?
67
PDB code
6kzo
Structure name
membrane protein
Structure deposition date
2019-09-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
nan
Peptide accession
O43497
Residue number A
271
Residue number B
323
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1G

Ligandability

Cysteine 271 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1G between cysteines 241 and 282.

Details

Redox score ?
66
PDB code
6kzo
Structure name
membrane protein
Structure deposition date
2019-09-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
nan
Peptide accession
O43497
Residue number A
241
Residue number B
282
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1G

Ligandability

Cysteine 241 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 282 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1G between cysteines 1419 and 1420 (1396 and 1397 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6kzp
Structure name
calcium channel-ligand
Structure deposition date
2019-09-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
48
Minimum pKa ?
10
% buried
60
Peptide accession
O43497
Residue number A
1419
Residue number B
1420
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1G

Ligandability

Cysteine 1419 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1420 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1G between cysteines 241 and 323. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6kzo
Structure name
membrane protein
Structure deposition date
2019-09-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
54
Peptide accession
O43497
Residue number A
241
Residue number B
323
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1G

Ligandability

Cysteine 241 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent T-type calcium channel subunit alpha-1G between cysteines 218 and 390. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
6kzo
Structure name
membrane protein
Structure deposition date
2019-09-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
88
Peptide accession
O43497
Residue number A
218
Residue number B
390
Peptide name
Voltage-dependent T-type calcium channel subunit alpha-1G

Ligandability

Cysteine 218 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 390 of Voltage-dependent T-type calcium channel subunit alpha-1G

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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