ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Potassium voltage-gated channel subfamily KQT member 2

Intramolecular
Cysteine 150 and cysteine 151
Cysteine 151 and cysteine 152
Cysteine 150 and cysteine 152
A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily KQT member 2 between cysteines 150 and 151. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7cr7
Structure name
human kcnq2-cam in complex with retigabine
Structure deposition date
2020-08-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
29
Peptide accession
O43526
Residue number A
150
Residue number B
151
Peptide name
Potassium voltage-gated channel subfamily KQT member 2

Ligandability

Cysteine 150 of Potassium voltage-gated channel subfamily KQT member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Potassium voltage-gated channel subfamily KQT member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily KQT member 2 between cysteines 151 and 152. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
7cr3
Structure name
human kcnq2-cam in apo state
Structure deposition date
2020-08-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
50
Peptide accession
O43526
Residue number A
151
Residue number B
152
Peptide name
Potassium voltage-gated channel subfamily KQT member 2

Ligandability

Cysteine 151 of Potassium voltage-gated channel subfamily KQT member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 152 of Potassium voltage-gated channel subfamily KQT member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily KQT member 2 between cysteines 150 and 152. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7cr3
Structure name
human kcnq2-cam in apo state
Structure deposition date
2020-08-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
63
Peptide accession
O43526
Residue number A
150
Residue number B
152
Peptide name
Potassium voltage-gated channel subfamily KQT member 2

Ligandability

Cysteine 150 of Potassium voltage-gated channel subfamily KQT member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 152 of Potassium voltage-gated channel subfamily KQT member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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