ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fibroblast growth factor receptor substrate 3

Intermolecular
Cysteine 91 and cysteine 1579 of ALK tyrosine kinase receptor
Intramolecular
Cysteine 61 and cysteine 80
A redox-regulated disulphide may form between cysteine 91 of Fibroblast growth factor receptor substrate 3 and cysteine 1579 of ALK tyrosine kinase receptor (91 and 9 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2ys5
Structure name
solution structure of the complex of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589) of halk
Structure deposition date
2007-04-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
56
Peptide A name
Fibroblast growth factor receptor substrate 3
Peptide B name
ALK tyrosine kinase receptor
Peptide A accession
O43559
Peptide B accession
Q9UM73
Peptide A residue number
91
Peptide B residue number
1579

Ligandability

Cysteine 91 of Fibroblast growth factor receptor substrate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1579 of ALK tyrosine kinase receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fibroblast growth factor receptor substrate 3 between cysteines 61 and 80.

Details

Redox score ?
72
PDB code
2kup
Structure name
solution structure of the complex of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589) of halk
Structure deposition date
2010-02-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
8
% buried
32
Peptide accession
O43559
Residue number A
61
Residue number B
80
Peptide name
Fibroblast growth factor receptor substrate 3

Ligandability

Cysteine 61 of Fibroblast growth factor receptor substrate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 80 of Fibroblast growth factor receptor substrate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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