a tool for identifying drug-targetable redox-active disulphides

Carbonic anhydrase 12

Intramolecular

Cysteine 50 and cysteine 230

A redox-regulated disulphide may form within Carbonic anhydrase 12 between cysteines 50 and 230 (22 and 202 respectively in this structure).

Details

Redox score ?

82

PDB code

Structure name

crystal structure of human carbonic anhydrase isozyme xii with 4-(1h- benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide

Structure deposition date

2016-07-27

Thiol separation (Å)

2

Half-sphere exposure sum ?

71

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

50

Residue number B

230

Peptide name

Carbonic anhydrase 12

Ligandability

Cysteine 50 of Carbonic anhydrase 12

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 230 of Carbonic anhydrase 12

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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