ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Density-regulated protein

Intramolecular
Cysteine 34 and cysteine 44
Cysteine 34 and cysteine 37
Cysteine 37 and cysteine 53
Cysteine 37 and cysteine 44
Cysteine 34 and cysteine 53
Cysteine 44 and cysteine 53
A redox-regulated disulphide may form within Density-regulated protein between cysteines 34 and 44.

Details

Redox score ?
89
PDB code
5ons
Structure name
crystal structure of the minimal denr-mcts1 complex
Structure deposition date
2017-08-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
6
% buried
0
Peptide accession
O43583
Residue number A
34
Residue number B
44
Peptide name
Density-regulated protein

Ligandability

Cysteine 34 of Density-regulated protein

Cysteine 44 of Density-regulated protein

A redox-regulated disulphide may form within Density-regulated protein between cysteines 34 and 37.

Details

Redox score ?
87
PDB code
5ons
Structure name
crystal structure of the minimal denr-mcts1 complex
Structure deposition date
2017-08-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
6
% buried
4
Peptide accession
O43583
Residue number A
34
Residue number B
37
Peptide name
Density-regulated protein

Ligandability

Cysteine 34 of Density-regulated protein

Cysteine 37 of Density-regulated protein

A redox-regulated disulphide may form within Density-regulated protein between cysteines 37 and 53.

Details

Redox score ?
83
PDB code
6ms4
Structure name
crystal structure of the denr-mct-1 complex
Structure deposition date
2018-10-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
5
% buried
39
Peptide accession
O43583
Residue number A
37
Residue number B
53
Peptide name
Density-regulated protein

Ligandability

Cysteine 37 of Density-regulated protein

Cysteine 53 of Density-regulated protein

A redox-regulated disulphide may form within Density-regulated protein between cysteines 37 and 44.

Details

Redox score ?
83
PDB code
6ms4
Structure name
crystal structure of the denr-mct-1 complex
Structure deposition date
2018-10-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
5
% buried
55
Peptide accession
O43583
Residue number A
37
Residue number B
44
Peptide name
Density-regulated protein

Ligandability

Cysteine 37 of Density-regulated protein

Cysteine 44 of Density-regulated protein

A redox-regulated disulphide may form within Density-regulated protein between cysteines 34 and 53.

Details

Redox score ?
81
PDB code
6ms4
Structure name
crystal structure of the denr-mct-1 complex
Structure deposition date
2018-10-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
8
% buried
32
Peptide accession
O43583
Residue number A
34
Residue number B
53
Peptide name
Density-regulated protein

Ligandability

Cysteine 34 of Density-regulated protein

Cysteine 53 of Density-regulated protein

A redox-regulated disulphide may form within Density-regulated protein between cysteines 44 and 53.

Details

Redox score ?
73
PDB code
6ms4
Structure name
crystal structure of the denr-mct-1 complex
Structure deposition date
2018-10-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
43
Peptide accession
O43583
Residue number A
44
Residue number B
53
Peptide name
Density-regulated protein

Ligandability

Cysteine 44 of Density-regulated protein

Cysteine 53 of Density-regulated protein

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