ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Galanin receptor type 2

Intramolecular
Cysteine 98 and cysteine 175
Cysteine 73 and cysteine 77
Cysteine 77 and cysteine 78
Cysteine 73 and cysteine 78
Cysteine 246 and cysteine 248
Cysteine 248 and cysteine 286
A redox-regulated disulphide may form within Galanin receptor type 2 between cysteines 98 and 175.

Details

Redox score ?
81
PDB code
7wq4
Structure name
galanin-bound galanin receptor 2 in complex with gq
Structure deposition date
2022-01-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43603
Residue number A
98
Residue number B
175
Peptide name
Galanin receptor type 2

Ligandability

Cysteine 98 of Galanin receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 175 of Galanin receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Galanin receptor type 2 between cysteines 73 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7xjk
Structure name
cryo-em structure of the galanin-bound galr2-minigq complex
Structure deposition date
2022-04-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
42
Peptide accession
O43603
Residue number A
73
Residue number B
77
Peptide name
Galanin receptor type 2

Ligandability

Cysteine 73 of Galanin receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Galanin receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Galanin receptor type 2 between cysteines 77 and 78. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7wq4
Structure name
galanin-bound galanin receptor 2 in complex with gq
Structure deposition date
2022-01-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
75
Peptide accession
O43603
Residue number A
77
Residue number B
78
Peptide name
Galanin receptor type 2

Ligandability

Cysteine 77 of Galanin receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 78 of Galanin receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Galanin receptor type 2 between cysteines 73 and 78. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7xjl
Structure name
cryo-em structure of the spexin-bound galr2-minigq complex
Structure deposition date
2022-04-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
49
Peptide accession
O43603
Residue number A
73
Residue number B
78
Peptide name
Galanin receptor type 2

Ligandability

Cysteine 73 of Galanin receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 78 of Galanin receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Galanin receptor type 2 between cysteines 246 and 248. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7xjk
Structure name
cryo-em structure of the galanin-bound galr2-minigq complex
Structure deposition date
2022-04-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
42
Peptide accession
O43603
Residue number A
246
Residue number B
248
Peptide name
Galanin receptor type 2

Ligandability

Cysteine 246 of Galanin receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Galanin receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Galanin receptor type 2 between cysteines 248 and 286. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7xjl
Structure name
cryo-em structure of the spexin-bound galr2-minigq complex
Structure deposition date
2022-04-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
50
Peptide accession
O43603
Residue number A
248
Residue number B
286
Peptide name
Galanin receptor type 2

Ligandability

Cysteine 248 of Galanin receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 286 of Galanin receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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