ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Pleiotropic regulator 1

Intramolecular
Cysteine 264 and cysteine 306
Cysteine 209 and cysteine 264
Cysteine 209 and cysteine 468
Cysteine 306 and cysteine 338
A redox-regulated disulphide may form within Pleiotropic regulator 1 between cysteines 264 and 306. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7dh6
Structure name
crystal structure of plrg1
Structure deposition date
2020-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
101
Minimum pKa ?
12
% buried
100
Peptide accession
O43660
Residue number A
264
Residue number B
306
Peptide name
Pleiotropic regulator 1

Ligandability

Cysteine 264 of Pleiotropic regulator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Pleiotropic regulator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pleiotropic regulator 1 between cysteines 209 and 264. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7dh6
Structure name
crystal structure of plrg1
Structure deposition date
2020-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
98
Minimum pKa ?
12
% buried
100
Peptide accession
O43660
Residue number A
209
Residue number B
264
Peptide name
Pleiotropic regulator 1

Ligandability

Cysteine 209 of Pleiotropic regulator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 264 of Pleiotropic regulator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pleiotropic regulator 1 between cysteines 209 and 468. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
6ff4
Structure name
human bact spliceosome core structure
Structure deposition date
2018-01-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
91
Minimum pKa ?
10
% buried
100
Peptide accession
O43660
Residue number A
209
Residue number B
468
Peptide name
Pleiotropic regulator 1

Ligandability

Cysteine 209 of Pleiotropic regulator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 468 of Pleiotropic regulator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pleiotropic regulator 1 between cysteines 306 and 338. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
7w5a
Structure name
the cryo-em structure of human pre-c*-ii complex
Structure deposition date
2021-11-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
100
Peptide accession
O43660
Residue number A
306
Residue number B
338
Peptide name
Pleiotropic regulator 1

Ligandability

Cysteine 306 of Pleiotropic regulator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 338 of Pleiotropic regulator 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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