ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein regulator of cytokinesis 1

Intramolecular
Cysteine 136 and cysteine 209 L
Cysteine 132 and cysteine 136 L
A redox-regulated disulphide may form within Protein regulator of cytokinesis 1 between cysteines 136 and 209.

Details

Redox score ?
80
PDB code
4l3i
Structure name
structure of the microtubule associated protein prc1 (protein regulator of cytokinesis 1)
Structure deposition date
2013-06-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
O43663
Residue number A
136
Residue number B
209
Peptide name
Protein regulator of cytokinesis 1

Ligandability

Cysteine 136 of Protein regulator of cytokinesis 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 209 of Protein regulator of cytokinesis 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein regulator of cytokinesis 1 between cysteines 132 and 136. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
4l3i
Structure name
structure of the microtubule associated protein prc1 (protein regulator of cytokinesis 1)
Structure deposition date
2013-06-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
3
Peptide accession
O43663
Residue number A
132
Residue number B
136
Peptide name
Protein regulator of cytokinesis 1

Ligandability

Cysteine 132 of Protein regulator of cytokinesis 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 136 of Protein regulator of cytokinesis 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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