a tool for identifying drug-targetable redox-active disulphides

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

Intramolecular

Cysteine 24 and cysteine 58

A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 between cysteines 24 and 58.

Details

Redox score ?

85

PDB code

Structure name

nmr solution structure of subunit b8 from human nadh-ubiquinone oxidoreductase complex i (ci-b8)

Structure deposition date

2004-01-13

Thiol separation (Å)

2

Half-sphere exposure sum ?

38

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

24

Residue number B

58

Peptide name

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

Ligandability

Cysteine 24 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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