ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Maleylacetoacetate isomerase

Intramolecular
Cysteine 154 and cysteine 165
Cysteine 16 and cysteine 165
A redox-regulated disulphide may form within Maleylacetoacetate isomerase between cysteines 154 and 165. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
1fw1
Structure name
glutathione transferase zeta/maleylacetoacetate isomerase
Structure deposition date
2000-09-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
92
Minimum pKa ?
11
% buried
100
Peptide accession
O43708
Residue number A
154
Residue number B
165
Peptide name
Maleylacetoacetate isomerase

Ligandability

Cysteine 154 of Maleylacetoacetate isomerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 165 of Maleylacetoacetate isomerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Maleylacetoacetate isomerase between cysteines 16 and 165. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
1fw1
Structure name
glutathione transferase zeta/maleylacetoacetate isomerase
Structure deposition date
2000-09-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
94
Minimum pKa ?
11
% buried
100
Peptide accession
O43708
Residue number A
16
Residue number B
165
Peptide name
Maleylacetoacetate isomerase

Ligandability

Cysteine 16 of Maleylacetoacetate isomerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 165 of Maleylacetoacetate isomerase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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