ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

TP53-regulated inhibitor of apoptosis 1

Intramolecular
Cysteine 18 and cysteine 37
Cysteine 8 and cysteine 47
A redox-regulated disulphide may form within TP53-regulated inhibitor of apoptosis 1 between cysteines 18 and 37 (387 and 406 respectively in this structure).

Details

Redox score ?
84
PDB code
6i4y
Structure name
x-ray structure of the human mitochondrial prelid3b-triap1 complex
Structure deposition date
2018-11-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43715
Residue number A
18
Residue number B
37
Peptide name
TP53-regulated inhibitor of apoptosis 1

Ligandability

Cysteine 18 of TP53-regulated inhibitor of apoptosis 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 37 of TP53-regulated inhibitor of apoptosis 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TP53-regulated inhibitor of apoptosis 1 between cysteines 8 and 47 (377 and 416 respectively in this structure).

Details

Redox score ?
78
PDB code
6i4y
Structure name
x-ray structure of the human mitochondrial prelid3b-triap1 complex
Structure deposition date
2018-11-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
99
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43715
Residue number A
8
Residue number B
47
Peptide name
TP53-regulated inhibitor of apoptosis 1

Ligandability

Cysteine 8 of TP53-regulated inhibitor of apoptosis 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of TP53-regulated inhibitor of apoptosis 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: