ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HIV Tat-specific factor 1

Intramolecular
Cysteine 295 and cysteine 328
Cysteine 186 and cysteine 187 L
A redox-regulated disulphide may form within HIV Tat-specific factor 1 between cysteines 295 and 328.

Details

Redox score ?
71
PDB code
6n3e
Structure name
structure of hiv tat-specific factor 1 u2af homology motif bound to u2af ligand motif 4
Structure deposition date
2018-11-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
9
% buried
84
Peptide accession
O43719
Residue number A
295
Residue number B
328
Peptide name
HIV Tat-specific factor 1

Ligandability

Cysteine 295 of HIV Tat-specific factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 328 of HIV Tat-specific factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HIV Tat-specific factor 1 between cysteines 186 and 187. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7q3l
Structure name
human 17s u2 snrnp 5' domain
Structure deposition date
2021-10-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
24
Peptide accession
O43719
Residue number A
186
Residue number B
187
Peptide name
HIV Tat-specific factor 1

Ligandability

Cysteine 186 of HIV Tat-specific factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 187 of HIV Tat-specific factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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