ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytohesin-3

Intermolecular
Cysteine 342 and cysteine 342
Intramolecular
Cysteine 177 and cysteine 190
Cysteine 292 and cysteine 342
Cysteine 177 and cysteine 179
A redox-regulated disulphide may form between two units of Cytohesin-3 at cysteines 342 and 342.

Details

Redox score ?
81
PDB code
1fhx
Structure name
structure of the pleckstrin homology domain from grp1 in complex with inositol 1,3,4,5-tetrakisphosphate
Structure deposition date
2000-08-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide A name
Cytohesin-3
Peptide B name
Cytohesin-3
Peptide A accession
O08967
Peptide B accession
O08967
Peptide A residue number
342
Peptide B residue number
342

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytohesin-3 between cysteines 177 and 190.

Details

Redox score ?
73
PDB code
2r09
Structure name
crystal structure of autoinhibited form of grp1 arf gtpase exchange factor
Structure deposition date
2007-08-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
7
% buried
79
Peptide accession
O08967
Residue number A
177
Residue number B
190
Peptide name
Cytohesin-3

Ligandability

Cysteine 177 of Cytohesin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 190 of Cytohesin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytohesin-3 between cysteines 292 and 342. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2r09
Structure name
crystal structure of autoinhibited form of grp1 arf gtpase exchange factor
Structure deposition date
2007-08-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
36
Peptide accession
O08967
Residue number A
292
Residue number B
342
Peptide name
Cytohesin-3

Ligandability

Cysteine 292 of Cytohesin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 342 of Cytohesin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytohesin-3 between cysteines 177 and 179. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6u3g
Structure name
best fitting antiparallel model for volume 2 of truncated dimeric cytohesin-3 (grp1; amino acids 14-399)
Structure deposition date
2019-08-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
8
% buried
56
Peptide accession
O43739
Residue number A
177
Residue number B
179
Peptide name
Cytohesin-3

Ligandability

Cysteine 177 of Cytohesin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Cytohesin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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