ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Speckle-type POZ protein

Intermolecular
Cysteine 361 and cysteine 361 L
Cysteine 44 and cysteine 361 L
Cysteine 184 and cysteine 184
Cysteine 23 and cysteine 68
Cysteine 23 and cysteine 159
Intramolecular
Cysteine 203 and cysteine 205
Cysteine 202 and cysteine 203
Cysteine 202 and cysteine 205
Cysteine 68 and cysteine 159
A redox-regulated disulphide may form between two units of Speckle-type POZ protein at cysteines 361 and 361.

Details

Redox score ?
86
PDB code
8dws
Structure name
full-length e47k spop
Structure deposition date
2022-08-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide A name
Speckle-type POZ protein
Peptide B name
Speckle-type POZ protein
Peptide A accession
O43791
Peptide B accession
O43791
Peptide A residue number
361
Peptide B residue number
361

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Speckle-type POZ protein at cysteines 44 and 361. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
8dwt
Structure name
spop w22r form 2
Structure deposition date
2022-08-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
26
Peptide A name
Speckle-type POZ protein
Peptide B name
Speckle-type POZ protein
Peptide A accession
O43791
Peptide B accession
O43791
Peptide A residue number
44
Peptide B residue number
361

Ligandability

Cysteine 44 of Speckle-type POZ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of Speckle-type POZ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Speckle-type POZ protein at cysteines 184 and 184. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3hu6
Structure name
structures of spop-substrate complexes: insights into molecular architectures of btb-cul3 ubiquitin ligases: spopmathx/btb/3-box- pucsbc1
Structure deposition date
2009-06-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
42
Peptide A name
Speckle-type POZ protein
Peptide B name
Speckle-type POZ protein
Peptide A accession
O43791
Peptide B accession
O43791
Peptide A residue number
184
Peptide B residue number
184

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Speckle-type POZ protein at cysteines 23 and 68. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
8dwv
Structure name
full-length wild type spop
Structure deposition date
2022-08-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
60
Peptide A name
Speckle-type POZ protein
Peptide B name
Speckle-type POZ protein
Peptide A accession
O43791
Peptide B accession
O43791
Peptide A residue number
23
Peptide B residue number
68

Ligandability

Cysteine 23 of Speckle-type POZ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 68 of Speckle-type POZ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Speckle-type POZ protein at cysteines 23 and 159. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
8dws
Structure name
full-length e47k spop
Structure deposition date
2022-08-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
79
Peptide A name
Speckle-type POZ protein
Peptide B name
Speckle-type POZ protein
Peptide A accession
O43791
Peptide B accession
O43791
Peptide A residue number
23
Peptide B residue number
159

Ligandability

Cysteine 23 of Speckle-type POZ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of Speckle-type POZ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Speckle-type POZ protein between cysteines 203 and 205.

Details

Redox score ?
73
PDB code
4j8z
Structure name
crystal structure of the human spop btb domain
Structure deposition date
2013-02-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
10
% buried
10
Peptide accession
O43791
Residue number A
203
Residue number B
205
Peptide name
Speckle-type POZ protein

Ligandability

Cysteine 203 of Speckle-type POZ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of Speckle-type POZ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Speckle-type POZ protein between cysteines 202 and 203. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
3htm
Structure name
structures of spop-substrate complexes: insights into molecular architectures of btb-cul3 ubiquitin ligases: spopbtb/3-box
Structure deposition date
2009-06-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
11
% buried
46
Peptide accession
O43791
Residue number A
202
Residue number B
203
Peptide name
Speckle-type POZ protein

Ligandability

Cysteine 202 of Speckle-type POZ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of Speckle-type POZ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Speckle-type POZ protein between cysteines 202 and 205. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3htm
Structure name
structures of spop-substrate complexes: insights into molecular architectures of btb-cul3 ubiquitin ligases: spopbtb/3-box
Structure deposition date
2009-06-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
42
Peptide accession
O43791
Residue number A
202
Residue number B
205
Peptide name
Speckle-type POZ protein

Ligandability

Cysteine 202 of Speckle-type POZ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of Speckle-type POZ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Speckle-type POZ protein between cysteines 68 and 159. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
3hqi
Structure name
structures of spop-substrate complexes: insights into molecular architectures of btb-cul3 ubiquitin ligases: spopmathx/btb/3-box- pucsbc1
Structure deposition date
2009-06-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
75
Peptide accession
O43791
Residue number A
68
Residue number B
159
Peptide name
Speckle-type POZ protein

Ligandability

Cysteine 68 of Speckle-type POZ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of Speckle-type POZ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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