ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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U3 small nucleolar RNA-interacting protein 2

Intramolecular
Cysteine 296 and cysteine 297 L
Cysteine 151 and cysteine 204
Cysteine 399 and cysteine 416
A redox-regulated disulphide may form within U3 small nucleolar RNA-interacting protein 2 between cysteines 296 and 297. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
4jxm
Structure name
crystal structure of rrp9 wd40 repeats
Structure deposition date
2013-03-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43818
Residue number A
296
Residue number B
297
Peptide name
U3 small nucleolar RNA-interacting protein 2

Ligandability

Cysteine 296 of U3 small nucleolar RNA-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 297 of U3 small nucleolar RNA-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within U3 small nucleolar RNA-interacting protein 2 between cysteines 151 and 204. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4j0w
Structure name
structure of u3-55k
Structure deposition date
2013-01-31
Thiol separation (Å)
6
Half-sphere exposure sum ?
99
Minimum pKa ?
11
% buried
100
Peptide accession
O43818
Residue number A
151
Residue number B
204
Peptide name
U3 small nucleolar RNA-interacting protein 2

Ligandability

Cysteine 151 of U3 small nucleolar RNA-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 204 of U3 small nucleolar RNA-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within U3 small nucleolar RNA-interacting protein 2 between cysteines 399 and 416. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4jxm
Structure name
crystal structure of rrp9 wd40 repeats
Structure deposition date
2013-03-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43818
Residue number A
399
Residue number B
416
Peptide name
U3 small nucleolar RNA-interacting protein 2

Ligandability

Cysteine 399 of U3 small nucleolar RNA-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 416 of U3 small nucleolar RNA-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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