ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tolloid-like protein 1

Intramolecular
Cysteine 190 and cysteine 346
Cysteine 213 and cysteine 232
A redox-regulated disulphide may form within Tolloid-like protein 1 between cysteines 190 and 346 (42 and 198 respectively in this structure).

Details

Redox score ?
85
PDB code
3edi
Structure name
crystal structure of tolloid-like protease 1 (tll-1) protease domain
Structure deposition date
2008-09-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43897
Residue number A
190
Residue number B
346
Peptide name
Tolloid-like protein 1

Ligandability

Cysteine 190 of Tolloid-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 346 of Tolloid-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tolloid-like protein 1 between cysteines 213 and 232 (65 and 84 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
3edi
Structure name
crystal structure of tolloid-like protease 1 (tll-1) protease domain
Structure deposition date
2008-09-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
37
Peptide accession
O43897
Residue number A
213
Residue number B
232
Peptide name
Tolloid-like protein 1

Ligandability

Cysteine 213 of Tolloid-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 232 of Tolloid-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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