ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Growth arrest-specific protein 2

Intramolecular
Cysteine 216 and cysteine 218
Cysteine 218 and cysteine 270
Cysteine 216 and cysteine 270
A redox-regulated disulphide may form within Growth arrest-specific protein 2 between cysteines 216 and 218 (23 and 25 respectively in this structure).

Details

Redox score ?
87
PDB code
1v5r
Structure name
solution structure of the gas2 domain of the growth arrest specific 2 protein
Structure deposition date
2003-11-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
8
% buried
0
Peptide accession
P11862
Residue number A
216
Residue number B
218
Peptide name
Growth arrest-specific protein 2

Ligandability

Cysteine 216 of Growth arrest-specific protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of Growth arrest-specific protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth arrest-specific protein 2 between cysteines 218 and 270 (25 and 77 respectively in this structure).

Details

Redox score ?
83
PDB code
1v5r
Structure name
solution structure of the gas2 domain of the growth arrest specific 2 protein
Structure deposition date
2003-11-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
33
Minimum pKa ?
8
% buried
0
Peptide accession
P11862
Residue number A
218
Residue number B
270
Peptide name
Growth arrest-specific protein 2

Ligandability

Cysteine 218 of Growth arrest-specific protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 270 of Growth arrest-specific protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Growth arrest-specific protein 2 between cysteines 216 and 270 (23 and 77 respectively in this structure).

Details

Redox score ?
80
PDB code
1v5r
Structure name
solution structure of the gas2 domain of the growth arrest specific 2 protein
Structure deposition date
2003-11-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
0
Peptide accession
P11862
Residue number A
216
Residue number B
270
Peptide name
Growth arrest-specific protein 2

Ligandability

Cysteine 216 of Growth arrest-specific protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 270 of Growth arrest-specific protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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