ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Exostosin-like 3

Intermolecular
Cysteine 793 and cysteine 915
Intramolecular
Cysteine 177 and cysteine 182
Cysteine 400 and cysteine 415
Cysteine 188 and cysteine 236
Cysteine 831 and cysteine 879
A redox-regulated disulphide may form between two units of Exostosin-like 3 at cysteines 793 and 915.

Details

Redox score ?
82
PDB code
7aua
Structure name
cryo-em structure of human exostosin-like 3 (extl3) in complex with udp
Structure deposition date
2020-11-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide A name
Exostosin-like 3
Peptide B name
Exostosin-like 3
Peptide A accession
O43909
Peptide B accession
O43909
Peptide A residue number
793
Peptide B residue number
915

Ligandability

Cysteine 793 of Exostosin-like 3

Cysteine 915 of Exostosin-like 3

A redox-regulated disulphide may form within Exostosin-like 3 between cysteines 177 and 182.

Details

Redox score ?
87
PDB code
7au2
Structure name
cryo-em structure of human exostosin-like 3 (extl3)
Structure deposition date
2020-11-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43909
Residue number A
177
Residue number B
182
Peptide name
Exostosin-like 3

Ligandability

Cysteine 177 of Exostosin-like 3

Cysteine 182 of Exostosin-like 3

A redox-regulated disulphide may form within Exostosin-like 3 between cysteines 400 and 415.

Details

Redox score ?
87
PDB code
7au2
Structure name
cryo-em structure of human exostosin-like 3 (extl3)
Structure deposition date
2020-11-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43909
Residue number A
400
Residue number B
415
Peptide name
Exostosin-like 3

Ligandability

Cysteine 400 of Exostosin-like 3

Cysteine 415 of Exostosin-like 3

A redox-regulated disulphide may form within Exostosin-like 3 between cysteines 188 and 236.

Details

Redox score ?
82
PDB code
7au2
Structure name
cryo-em structure of human exostosin-like 3 (extl3)
Structure deposition date
2020-11-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43909
Residue number A
188
Residue number B
236
Peptide name
Exostosin-like 3

Ligandability

Cysteine 188 of Exostosin-like 3

Cysteine 236 of Exostosin-like 3

A redox-regulated disulphide may form within Exostosin-like 3 between cysteines 831 and 879.

Details

Redox score ?
82
PDB code
7aua
Structure name
cryo-em structure of human exostosin-like 3 (extl3) in complex with udp
Structure deposition date
2020-11-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43909
Residue number A
831
Residue number B
879
Peptide name
Exostosin-like 3

Ligandability

Cysteine 831 of Exostosin-like 3

Cysteine 879 of Exostosin-like 3

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