ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Origin recognition complex subunit 5

Intermolecular
Cysteine 194 of Origin recognition complex subunit 4 and cysteine 171
Intramolecular
Cysteine 63 and cysteine 66
A redox-regulated disulphide may form between cysteine 194 of Origin recognition complex subunit 4 and cysteine 171 of Origin recognition complex subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7jpr
Structure name
orc-open: human origin recognition complex (orc) in an open conformation
Structure deposition date
2020-08-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
100
Peptide A name
Origin recognition complex subunit 4
Peptide B name
Origin recognition complex subunit 5
Peptide A accession
O43929
Peptide B accession
O43913
Peptide A residue number
194
Peptide B residue number
171

Ligandability

Cysteine 194 of Origin recognition complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 171 of Origin recognition complex subunit 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Origin recognition complex subunit 5 between cysteines 63 and 66. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
5uj7
Structure name
structure of the active form of human origin recognition complex atpase motor module, complex subunits 1, 4, 5
Structure deposition date
2017-01-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
11
% buried
58
Peptide accession
O43913
Residue number A
63
Residue number B
66
Peptide name
Origin recognition complex subunit 5

Ligandability

Cysteine 63 of Origin recognition complex subunit 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Origin recognition complex subunit 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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