ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Intramolecular
Cysteine 43 and cysteine 56
Cysteine 33 and cysteine 66
A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 between cysteines 43 and 56.

Details

Redox score ?
85
PDB code
7dgz
Structure name
activity optimized complex i (closed form)
Structure deposition date
2020-11-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q02379
Residue number A
43
Residue number B
56
Peptide name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Ligandability

Cysteine 43 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 56 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 between cysteines 33 and 66 (32 and 65 respectively in this structure).

Details

Redox score ?
79
PDB code
7ak5
Structure name
cryo-em structure of respiratory complex i in the deactive state from mus musculus at 3
Structure deposition date
2020-09-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
74
Minimum pKa ?
5
% buried
100
Peptide accession
Q99LY9
Residue number A
33
Residue number B
66
Peptide name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Ligandability

Cysteine 33 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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