ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ephrin-A2

Intramolecular
Cysteine 73 and cysteine 114
Cysteine 102 and cysteine 163
A redox-regulated disulphide may form within Ephrin-A2 between cysteines 73 and 114.

Details

Redox score ?
84
PDB code
2wo3
Structure name
crystal structure of the epha4-ephrina2 complex
Structure deposition date
2009-07-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43921
Residue number A
73
Residue number B
114
Peptide name
Ephrin-A2

Ligandability

Cysteine 73 of Ephrin-A2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of Ephrin-A2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ephrin-A2 between cysteines 102 and 163.

Details

Redox score ?
82
PDB code
2wo3
Structure name
crystal structure of the epha4-ephrina2 complex
Structure deposition date
2009-07-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O43921
Residue number A
102
Residue number B
163
Peptide name
Ephrin-A2

Ligandability

Cysteine 102 of Ephrin-A2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 163 of Ephrin-A2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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