Origin recognition complex subunit 4
Intermolecular
Cysteine 829 of Origin recognition complex subunit 1 and cysteine 194
Cysteine 194 and cysteine 171 of Origin recognition complex subunit 5
Intramolecular
Cysteine 327 and cysteine 421
5uj7 A 829 C 194
A redox-regulated disulphide may form between cysteine 829 of Origin recognition complex subunit 1 and cysteine 194 of Origin recognition complex subunit 4. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
5uj7
Structure name
structure of the active form of human origin recognition complex atpase motor module, complex subunits 1, 4, 5
Structure deposition date
2017-01-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
100
Peptide A name
Origin recognition complex subunit 1
Peptide B name
Origin recognition complex subunit 4
Peptide A accession
Q13415
Peptide B accession
O43929
Peptide A residue number
829
Peptide B residue number
194
Ligandability
Cysteine 829 of Origin recognition complex subunit 1
Cysteine 194 of Origin recognition complex subunit 4
7jpr D 194 E 171
A redox-regulated disulphide may form between cysteine 194 of Origin recognition complex subunit 4 and cysteine 171 of Origin recognition complex subunit 5. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7jpr
Structure name
orc-open: human origin recognition complex (orc) in an open conformation
Structure deposition date
2020-08-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
100
Peptide A name
Origin recognition complex subunit 4
Peptide B name
Origin recognition complex subunit 5
Peptide A accession
O43929
Peptide B accession
O43913
Peptide A residue number
194
Peptide B residue number
171
Ligandability
Cysteine 194 of Origin recognition complex subunit 4
Cysteine 171 of Origin recognition complex subunit 5
5uj7 C 327 C 421
A redox-regulated disulphide may form within Origin recognition complex subunit 4 between cysteines 327 and 421. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
5uj7
Structure name
structure of the active form of human origin recognition complex atpase motor module, complex subunits 1, 4, 5
Structure deposition date
2017-01-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
71
Peptide accession
O43929
Residue number A
327
Residue number B
421
Peptide name
Origin recognition complex subunit 4
Ligandability
Cysteine 327 of Origin recognition complex subunit 4
Cysteine 421 of Origin recognition complex subunit 4
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