ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MHC class I DLA-88

Intramolecular
Cysteine 125 and cysteine 188
Cysteine 227 and cysteine 283
A redox-regulated disulphide may form within MHC class I DLA-88 between cysteines 125 and 188 (102 and 165 respectively in this structure).

Details

Redox score ?
82
PDB code
7cjq
Structure name
structure of dla-88*001:01
Structure deposition date
2020-07-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O46882
Residue number A
125
Residue number B
188
Peptide name
MHC class I DLA-88

Ligandability

Cysteine 125 of MHC class I DLA-88

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 188 of MHC class I DLA-88

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I DLA-88 between cysteines 227 and 283 (204 and 260 respectively in this structure).

Details

Redox score ?
80
PDB code
7cjq
Structure name
structure of dla-88*001:01
Structure deposition date
2020-07-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
O46882
Residue number A
227
Residue number B
283
Peptide name
MHC class I DLA-88

Ligandability

Cysteine 227 of MHC class I DLA-88

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of MHC class I DLA-88

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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