ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Intramolecular
Cysteine 456 and cysteine 457
Cysteine 519 and cysteine 527
A redox-regulated disulphide may form within SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 between cysteines 456 and 457. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6ne3
Structure name
cryo-em structure of singly-bound snf2h-nucleosome complex with snf2h bound at shl-2
Structure deposition date
2018-12-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
86
Peptide accession
O60264
Residue number A
456
Residue number B
457
Peptide name
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Ligandability

Cysteine 456 of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 457 of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 between cysteines 519 and 527. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
6ne3
Structure name
cryo-em structure of singly-bound snf2h-nucleosome complex with snf2h bound at shl-2
Structure deposition date
2018-12-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
62
Peptide accession
O60264
Residue number A
519
Residue number B
527
Peptide name
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Ligandability

Cysteine 519 of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 527 of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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