ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Suppression of tumorigenicity 18 protein

Intramolecular
Cysteine 816 and cysteine 821
Cysteine 869 and cysteine 874
Cysteine 821 and cysteine 840
Cysteine 874 and cysteine 893
Cysteine 869 and cysteine 893
Cysteine 816 and cysteine 840
A redox-regulated disulphide may form within Suppression of tumorigenicity 18 protein between cysteines 816 and 821 (12 and 17 respectively in this structure).

Details

Redox score ?
90
PDB code
2cs8
Structure name
solution structure of tandem repeat of the fifth and sixth zinc-finger c2hc domains from human st18
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
7
% buried
0
Peptide accession
O60284
Residue number A
816
Residue number B
821
Peptide name
Suppression of tumorigenicity 18 protein

Ligandability

Cysteine 816 of Suppression of tumorigenicity 18 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 821 of Suppression of tumorigenicity 18 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Suppression of tumorigenicity 18 protein between cysteines 869 and 874 (65 and 70 respectively in this structure).

Details

Redox score ?
88
PDB code
2cs8
Structure name
solution structure of tandem repeat of the fifth and sixth zinc-finger c2hc domains from human st18
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
8
% buried
0
Peptide accession
O60284
Residue number A
869
Residue number B
874
Peptide name
Suppression of tumorigenicity 18 protein

Ligandability

Cysteine 869 of Suppression of tumorigenicity 18 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 874 of Suppression of tumorigenicity 18 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Suppression of tumorigenicity 18 protein between cysteines 821 and 840 (17 and 36 respectively in this structure).

Details

Redox score ?
87
PDB code
2cs8
Structure name
solution structure of tandem repeat of the fifth and sixth zinc-finger c2hc domains from human st18
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
7
% buried
0
Peptide accession
O60284
Residue number A
821
Residue number B
840
Peptide name
Suppression of tumorigenicity 18 protein

Ligandability

Cysteine 821 of Suppression of tumorigenicity 18 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 840 of Suppression of tumorigenicity 18 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Suppression of tumorigenicity 18 protein between cysteines 874 and 893 (70 and 89 respectively in this structure).

Details

Redox score ?
85
PDB code
2cs8
Structure name
solution structure of tandem repeat of the fifth and sixth zinc-finger c2hc domains from human st18
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
8
% buried
0
Peptide accession
O60284
Residue number A
874
Residue number B
893
Peptide name
Suppression of tumorigenicity 18 protein

Ligandability

Cysteine 874 of Suppression of tumorigenicity 18 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 893 of Suppression of tumorigenicity 18 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Suppression of tumorigenicity 18 protein between cysteines 869 and 893 (65 and 89 respectively in this structure).

Details

Redox score ?
85
PDB code
2cs8
Structure name
solution structure of tandem repeat of the fifth and sixth zinc-finger c2hc domains from human st18
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
0
Peptide accession
O60284
Residue number A
869
Residue number B
893
Peptide name
Suppression of tumorigenicity 18 protein

Ligandability

Cysteine 869 of Suppression of tumorigenicity 18 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 893 of Suppression of tumorigenicity 18 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Suppression of tumorigenicity 18 protein between cysteines 816 and 840 (12 and 36 respectively in this structure).

Details

Redox score ?
84
PDB code
2cs8
Structure name
solution structure of tandem repeat of the fifth and sixth zinc-finger c2hc domains from human st18
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
8
% buried
0
Peptide accession
O60284
Residue number A
816
Residue number B
840
Peptide name
Suppression of tumorigenicity 18 protein

Ligandability

Cysteine 816 of Suppression of tumorigenicity 18 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 840 of Suppression of tumorigenicity 18 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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