ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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RNA helicase aquarius

Intramolecular
Cysteine 1215 and cysteine 1245
Cysteine 562 and cysteine 595
Cysteine 95 and cysteine 96
Cysteine 95 and cysteine 153
Cysteine 250 and cysteine 283
A redox-regulated disulphide may form within RNA helicase aquarius between cysteines 1215 and 1245. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
4pj3
Structure name
structural insight into the function and evolution of the spliceosomal helicase aquarius, structure of aquarius in complex with amppnp
Structure deposition date
2014-05-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
11
% buried
72
Peptide accession
O60306
Residue number A
1215
Residue number B
1245
Peptide name
RNA helicase aquarius

Ligandability

Cysteine 1215 of RNA helicase aquarius

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1245 of RNA helicase aquarius

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA helicase aquarius between cysteines 562 and 595. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
4pj3
Structure name
structural insight into the function and evolution of the spliceosomal helicase aquarius, structure of aquarius in complex with amppnp
Structure deposition date
2014-05-11
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
100
Peptide accession
O60306
Residue number A
562
Residue number B
595
Peptide name
RNA helicase aquarius

Ligandability

Cysteine 562 of RNA helicase aquarius

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 595 of RNA helicase aquarius

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA helicase aquarius between cysteines 95 and 96. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
4pj3
Structure name
structural insight into the function and evolution of the spliceosomal helicase aquarius, structure of aquarius in complex with amppnp
Structure deposition date
2014-05-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
12
% buried
100
Peptide accession
O60306
Residue number A
95
Residue number B
96
Peptide name
RNA helicase aquarius

Ligandability

Cysteine 95 of RNA helicase aquarius

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of RNA helicase aquarius

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA helicase aquarius between cysteines 95 and 153. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4pj3
Structure name
structural insight into the function and evolution of the spliceosomal helicase aquarius, structure of aquarius in complex with amppnp
Structure deposition date
2014-05-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
13
% buried
100
Peptide accession
O60306
Residue number A
95
Residue number B
153
Peptide name
RNA helicase aquarius

Ligandability

Cysteine 95 of RNA helicase aquarius

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 153 of RNA helicase aquarius

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA helicase aquarius between cysteines 250 and 283. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
4pj3
Structure name
structural insight into the function and evolution of the spliceosomal helicase aquarius, structure of aquarius in complex with amppnp
Structure deposition date
2014-05-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
13
% buried
100
Peptide accession
O60306
Residue number A
250
Residue number B
283
Peptide name
RNA helicase aquarius

Ligandability

Cysteine 250 of RNA helicase aquarius

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of RNA helicase aquarius

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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