ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Centrosomal protein of 104 kDa

Intramolecular
Cysteine 812 and cysteine 833
Cysteine 786 and cysteine 803
Cysteine 812 and cysteine 815
Cysteine 754 and cysteine 757
Cysteine 754 and cysteine 777
Cysteine 848 and cysteine 869
Cysteine 783 and cysteine 803
Cysteine 783 and cysteine 786
Cysteine 845 and cysteine 869
Cysteine 757 and cysteine 777
More...
Cysteine 845 and cysteine 848
Cysteine 815 and cysteine 833
A redox-regulated disulphide may form within Centrosomal protein of 104 kDa between cysteines 812 and 833.

Details

Redox score ?
86
PDB code
5lpi
Structure name
structure of the zinc finger array of cep104
Structure deposition date
2016-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
7
% buried
10
Peptide accession
O60308
Residue number A
812
Residue number B
833
Peptide name
Centrosomal protein of 104 kDa

Ligandability

Cysteine 812 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 833 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centrosomal protein of 104 kDa between cysteines 786 and 803.

Details

Redox score ?
84
PDB code
5lpi
Structure name
structure of the zinc finger array of cep104
Structure deposition date
2016-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
7
% buried
26
Peptide accession
O60308
Residue number A
786
Residue number B
803
Peptide name
Centrosomal protein of 104 kDa

Ligandability

Cysteine 786 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 803 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centrosomal protein of 104 kDa between cysteines 812 and 815.

Details

Redox score ?
84
PDB code
5lpi
Structure name
structure of the zinc finger array of cep104
Structure deposition date
2016-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
7
% buried
21
Peptide accession
O60308
Residue number A
812
Residue number B
815
Peptide name
Centrosomal protein of 104 kDa

Ligandability

Cysteine 812 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 815 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centrosomal protein of 104 kDa between cysteines 754 and 757.

Details

Redox score ?
82
PDB code
5lpi
Structure name
structure of the zinc finger array of cep104
Structure deposition date
2016-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
7
% buried
38
Peptide accession
O60308
Residue number A
754
Residue number B
757
Peptide name
Centrosomal protein of 104 kDa

Ligandability

Cysteine 754 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 757 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centrosomal protein of 104 kDa between cysteines 754 and 777.

Details

Redox score ?
82
PDB code
5lpi
Structure name
structure of the zinc finger array of cep104
Structure deposition date
2016-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
7
% buried
46
Peptide accession
O60308
Residue number A
754
Residue number B
777
Peptide name
Centrosomal protein of 104 kDa

Ligandability

Cysteine 754 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 777 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centrosomal protein of 104 kDa between cysteines 848 and 869.

Details

Redox score ?
81
PDB code
5lpi
Structure name
structure of the zinc finger array of cep104
Structure deposition date
2016-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
24
Peptide accession
O60308
Residue number A
848
Residue number B
869
Peptide name
Centrosomal protein of 104 kDa

Ligandability

Cysteine 848 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 869 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centrosomal protein of 104 kDa between cysteines 783 and 803.

Details

Redox score ?
81
PDB code
5lpi
Structure name
structure of the zinc finger array of cep104
Structure deposition date
2016-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
40
Peptide accession
O60308
Residue number A
783
Residue number B
803
Peptide name
Centrosomal protein of 104 kDa

Ligandability

Cysteine 783 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 803 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centrosomal protein of 104 kDa between cysteines 783 and 786.

Details

Redox score ?
80
PDB code
5lpi
Structure name
structure of the zinc finger array of cep104
Structure deposition date
2016-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
6
% buried
nan
Peptide accession
O60308
Residue number A
783
Residue number B
786
Peptide name
Centrosomal protein of 104 kDa

Ligandability

Cysteine 783 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 786 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centrosomal protein of 104 kDa between cysteines 845 and 869.

Details

Redox score ?
79
PDB code
5lpi
Structure name
structure of the zinc finger array of cep104
Structure deposition date
2016-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
46
Peptide accession
O60308
Residue number A
845
Residue number B
869
Peptide name
Centrosomal protein of 104 kDa

Ligandability

Cysteine 845 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 869 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centrosomal protein of 104 kDa between cysteines 757 and 777.

Details

Redox score ?
76
PDB code
5lpi
Structure name
structure of the zinc finger array of cep104
Structure deposition date
2016-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
47
Peptide accession
O60308
Residue number A
757
Residue number B
777
Peptide name
Centrosomal protein of 104 kDa

Ligandability

Cysteine 757 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 777 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centrosomal protein of 104 kDa between cysteines 845 and 848.

Details

Redox score ?
73
PDB code
5lpi
Structure name
structure of the zinc finger array of cep104
Structure deposition date
2016-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
42
Peptide accession
O60308
Residue number A
845
Residue number B
848
Peptide name
Centrosomal protein of 104 kDa

Ligandability

Cysteine 845 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 848 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Centrosomal protein of 104 kDa between cysteines 815 and 833. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
5lpi
Structure name
structure of the zinc finger array of cep104
Structure deposition date
2016-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
18
% buried
nan
Peptide accession
O60308
Residue number A
815
Residue number B
833
Peptide name
Centrosomal protein of 104 kDa

Ligandability

Cysteine 815 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 833 of Centrosomal protein of 104 kDa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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