ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Germinal-center associated nuclear protein

Intermolecular
Cysteine 1189 and cysteine 50 of Transcription and mRNA export factor ENY2
Intramolecular
Cysteine 1208 and cysteine 1209
Cysteine 1209 and cysteine 1213
A redox-regulated disulphide may form between cysteine 1189 of Germinal-center associated nuclear protein and cysteine 50 of Transcription and mRNA export factor ENY2 (1188 and 50 respectively in this structure).

Details

Redox score ?
77
PDB code
4dhx
Structure name
eny2:ganp complex
Structure deposition date
2012-01-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
8
% buried
58
Peptide A name
Germinal-center associated nuclear protein
Peptide B name
Transcription and mRNA export factor ENY2
Peptide A accession
O60318
Peptide B accession
Q9NPA8
Peptide A residue number
1189
Peptide B residue number
50

Ligandability

Cysteine 1189 of Germinal-center associated nuclear protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 50 of Transcription and mRNA export factor ENY2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Germinal-center associated nuclear protein between cysteines 1208 and 1209 (1207 and 1208 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
4dhx
Structure name
eny2:ganp complex
Structure deposition date
2012-01-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
20
Peptide accession
O60318
Residue number A
1208
Residue number B
1209
Peptide name
Germinal-center associated nuclear protein

Ligandability

Cysteine 1208 of Germinal-center associated nuclear protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1209 of Germinal-center associated nuclear protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Germinal-center associated nuclear protein between cysteines 1209 and 1213 (1208 and 1212 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4dhx
Structure name
eny2:ganp complex
Structure deposition date
2012-01-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
54
Peptide accession
O60318
Residue number A
1209
Residue number B
1213
Peptide name
Germinal-center associated nuclear protein

Ligandability

Cysteine 1209 of Germinal-center associated nuclear protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1213 of Germinal-center associated nuclear protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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