a tool for identifying drug-targetable redox-active disulphides

Kinesin-like protein KIF1B

Intramolecular

Cysteine 581 and cysteine 600

A redox-regulated disulphide may form within Kinesin-like protein KIF1B between cysteines 581 and 600 (58 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

41

PDB code

Structure name

solution structure of the fha domain from human kinesin-like protein kif1b

Structure deposition date

2007-03-02

Thiol separation (Å)

9

Half-sphere exposure sum ?

68

Minimum pK_a ?

9

% buried

52

Peptide accession

Residue number A

581

Residue number B

600

Peptide name

Kinesin-like protein KIF1B

Ligandability

Cysteine 581 of Kinesin-like protein KIF1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 600 of Kinesin-like protein KIF1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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