Lysine-specific histone demethylase 1A

Intramolecular

A redox-regulated disulphide may form within Lysine-specific histone demethylase 1A between cysteines 600 and 618 (604 and 622 respectively in this structure).

Details

Redox score ?

PDB code

5lgn

Structure name

thieno[3,2-b]pyrrole-5-carboxamides as novel reversible inhibitors of histone lysine demethylase kdm1a/lsd1: compound 19

Structure deposition date

2016-07-07

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

O60341

Residue number A

600

Residue number B

618

Peptide name

Lysine-specific histone demethylase 1A

Ligandability

Cysteine 600 of Lysine-specific histone demethylase 1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.