a tool for identifying drug-targetable redox-active disulphides

TBC1 domain family member 4

Intramolecular

Cysteine 900 and cysteine 906

A redox-regulated disulphide may form within TBC1 domain family member 4 between cysteines 900 and 906 (901 and 907 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

52

PDB code

Structure name

x-ray crystal structure of human tbc1d4 (as160) rabgap domain

Structure deposition date

2011-03-03

Thiol separation (Å)

9

Half-sphere exposure sum ?

34

Minimum pK_a ?

9

% buried

7

Peptide accession

Residue number A

900

Residue number B

906

Peptide name

TBC1 domain family member 4

Ligandability

Cysteine 900 of TBC1 domain family member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 906 of TBC1 domain family member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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