ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Voltage-dependent calcium channel gamma-3 subunit

Intramolecular
Cysteine 40 and cysteine 68
Cysteine 718 and cysteine 40
Cysteine 67 and cysteine 77
Cysteine 68 and cysteine 77
Cysteine 40 and cysteine 77
Cysteine 67 and cysteine 68
Cysteine 40 and cysteine 67
A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-3 subunit between cysteines 40 and 68 (1039 and 1067 respectively in this structure).

Details

Redox score ?
87
PDB code
7tnj
Structure name
complex nnnn of ampa-subtype iglur glua2 in complex with auxiliary subunit gamma2 (stargazin) at low glutamate concentration (20 um) in the presence of cyclothiazide (100 um)
Structure deposition date
2022-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHX0
Residue number A
40
Residue number B
68
Peptide name
Voltage-dependent calcium channel gamma-3 subunit

Ligandability

Cysteine 40 of Voltage-dependent calcium channel gamma-3 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 68 of Voltage-dependent calcium channel gamma-3 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-3 subunit between cysteines 718 and 40 (718 and 773 respectively in this structure).

Details

Redox score ?
84
PDB code
7tnj
Structure name
complex nnnn of ampa-subtype iglur glua2 in complex with auxiliary subunit gamma2 (stargazin) at low glutamate concentration (20 um) in the presence of cyclothiazide (100 um)
Structure deposition date
2022-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHX0
Residue number A
718
Residue number B
40
Peptide name
Voltage-dependent calcium channel gamma-3 subunit

Ligandability

Cysteine 718 of Voltage-dependent calcium channel gamma-3 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 40 of Voltage-dependent calcium channel gamma-3 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 718 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-3 subunit between cysteines 67 and 77 (1066 and 1076 respectively in this structure).

Details

Redox score ?
81
PDB code
7tnj
Structure name
complex nnnn of ampa-subtype iglur glua2 in complex with auxiliary subunit gamma2 (stargazin) at low glutamate concentration (20 um) in the presence of cyclothiazide (100 um)
Structure deposition date
2022-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHX0
Residue number A
67
Residue number B
77
Peptide name
Voltage-dependent calcium channel gamma-3 subunit

Ligandability

Cysteine 67 of Voltage-dependent calcium channel gamma-3 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Voltage-dependent calcium channel gamma-3 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-3 subunit between cysteines 68 and 77 (1067 and 1076 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7tnl
Structure name
complex gngn1 of ampa-subtype iglur glua2 in complex with auxiliary subunit gamma2 (stargazin) at low glutamate concentration (20 um) in the presence of cyclothiazide (100 um)
Structure deposition date
2022-01-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHX0
Residue number A
68
Residue number B
77
Peptide name
Voltage-dependent calcium channel gamma-3 subunit

Ligandability

Cysteine 68 of Voltage-dependent calcium channel gamma-3 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Voltage-dependent calcium channel gamma-3 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-3 subunit between cysteines 40 and 77 (1039 and 1076 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7tnk
Structure name
complex gnnn of ampa-subtype iglur glua2 in complex with auxiliary subunit gamma2 (stargazin) at low glutamate concentration (20 um) in the presence of cyclothiazide (100 um)
Structure deposition date
2022-01-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHX0
Residue number A
40
Residue number B
77
Peptide name
Voltage-dependent calcium channel gamma-3 subunit

Ligandability

Cysteine 40 of Voltage-dependent calcium channel gamma-3 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Voltage-dependent calcium channel gamma-3 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-3 subunit between cysteines 67 and 68 (1066 and 1067 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7tnk
Structure name
complex gnnn of ampa-subtype iglur glua2 in complex with auxiliary subunit gamma2 (stargazin) at low glutamate concentration (20 um) in the presence of cyclothiazide (100 um)
Structure deposition date
2022-01-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHX0
Residue number A
67
Residue number B
68
Peptide name
Voltage-dependent calcium channel gamma-3 subunit

Ligandability

Cysteine 67 of Voltage-dependent calcium channel gamma-3 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 68 of Voltage-dependent calcium channel gamma-3 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel gamma-3 subunit between cysteines 40 and 67 (1039 and 1066 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7tnm
Structure name
complex gngn2 of ampa-subtype iglur glua2 in complex with auxiliary subunit gamma2 (stargazin) at low glutamate concentration (20 um) in the presence of cyclothiazide (100 um)
Structure deposition date
2022-01-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHX0
Residue number A
40
Residue number B
67
Peptide name
Voltage-dependent calcium channel gamma-3 subunit

Ligandability

Cysteine 40 of Voltage-dependent calcium channel gamma-3 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 67 of Voltage-dependent calcium channel gamma-3 subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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