ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Glutamate receptor ionotropic, NMDA 3B

Intramolecular
Cysteine 439 and cysteine 475
Cysteine 445 and cysteine 476
Cysteine 439 and cysteine 476
Cysteine 439 and cysteine 445
Cysteine 475 and cysteine 476
Cysteine 445 and cysteine 475
Cysteine 476 and cysteine 480
A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 3B between cysteines 439 and 475 (29 and 65 respectively in this structure).

Details

Redox score ?
84
PDB code
2rca
Structure name
crystal structure of the nr3b ligand binding core complex with glycine at 1
Structure deposition date
2007-09-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHN2
Residue number A
439
Residue number B
475
Peptide name
Glutamate receptor ionotropic, NMDA 3B

Ligandability

Cysteine 439 of Glutamate receptor ionotropic, NMDA 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 475 of Glutamate receptor ionotropic, NMDA 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 3B between cysteines 445 and 476 (35 and 66 respectively in this structure).

Details

Redox score ?
68
PDB code
2rca
Structure name
crystal structure of the nr3b ligand binding core complex with glycine at 1
Structure deposition date
2007-09-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
49
Peptide accession
Q8VHN2
Residue number A
445
Residue number B
476
Peptide name
Glutamate receptor ionotropic, NMDA 3B

Ligandability

Cysteine 445 of Glutamate receptor ionotropic, NMDA 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 476 of Glutamate receptor ionotropic, NMDA 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 3B between cysteines 439 and 476 (29 and 66 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
2rca
Structure name
crystal structure of the nr3b ligand binding core complex with glycine at 1
Structure deposition date
2007-09-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHN2
Residue number A
439
Residue number B
476
Peptide name
Glutamate receptor ionotropic, NMDA 3B

Ligandability

Cysteine 439 of Glutamate receptor ionotropic, NMDA 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 476 of Glutamate receptor ionotropic, NMDA 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 3B between cysteines 439 and 445 (29 and 35 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2rca
Structure name
crystal structure of the nr3b ligand binding core complex with glycine at 1
Structure deposition date
2007-09-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHN2
Residue number A
439
Residue number B
445
Peptide name
Glutamate receptor ionotropic, NMDA 3B

Ligandability

Cysteine 439 of Glutamate receptor ionotropic, NMDA 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 445 of Glutamate receptor ionotropic, NMDA 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 3B between cysteines 475 and 476 (65 and 66 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2rcb
Structure name
crystal structure of the nr3b ligand binding core complex with d- serine at 1
Structure deposition date
2007-09-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHN2
Residue number A
475
Residue number B
476
Peptide name
Glutamate receptor ionotropic, NMDA 3B

Ligandability

Cysteine 475 of Glutamate receptor ionotropic, NMDA 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 476 of Glutamate receptor ionotropic, NMDA 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 3B between cysteines 445 and 475 (35 and 65 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2rca
Structure name
crystal structure of the nr3b ligand binding core complex with glycine at 1
Structure deposition date
2007-09-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VHN2
Residue number A
445
Residue number B
475
Peptide name
Glutamate receptor ionotropic, NMDA 3B

Ligandability

Cysteine 445 of Glutamate receptor ionotropic, NMDA 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 475 of Glutamate receptor ionotropic, NMDA 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutamate receptor ionotropic, NMDA 3B between cysteines 476 and 480 (66 and 70 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
2rca
Structure name
crystal structure of the nr3b ligand binding core complex with glycine at 1
Structure deposition date
2007-09-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
74
Peptide accession
Q8VHN2
Residue number A
476
Residue number B
480
Peptide name
Glutamate receptor ionotropic, NMDA 3B

Ligandability

Cysteine 476 of Glutamate receptor ionotropic, NMDA 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 480 of Glutamate receptor ionotropic, NMDA 3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: