Neuropilin-2
Intermolecular
Cysteine 434 and cysteine 434
Intramolecular
Cysteine 208 and cysteine 230
Cysteine 83 and cysteine 105
Cysteine 28 and cysteine 55
Cysteine 277 and cysteine 427
Cysteine 434 and cysteine 592
Cysteine 149 and cysteine 175
4qds A 434 B 434
A redox-regulated disulphide may form between two units of Neuropilin-2 at cysteines 434 and 434.
Details
Redox score ?
88
PDB code
4qds
Structure name
physical basis for nrp2 ligand binding
Structure deposition date
2014-05-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide A name
Neuropilin-2
Peptide B name
Neuropilin-2
Peptide A accession
O60462
Peptide B accession
O60462
Peptide A residue number
434
Peptide B residue number
434
Ligandability
2qqo A 208 A 230
A redox-regulated disulphide may form within Neuropilin-2 between cysteines 208 and 230.
Details
Redox score ?
88
PDB code
2qqo
Structure name
crystal structure of the a2b1b2 domains from human neuropilin-2
Structure deposition date
2007-07-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60462
Residue number A
208
Residue number B
230
Peptide name
Neuropilin-2
Ligandability
Cysteine 208 of Neuropilin-2
Cysteine 230 of Neuropilin-2
6gh8 A 83 A 105
A redox-regulated disulphide may form within Neuropilin-2 between cysteines 83 and 105.
Details
Redox score ?
88
PDB code
6gh8
Structure name
crystal structure of gp1 domain of lujo virus in complex with the first cub domain of neuropilin-2
Structure deposition date
2018-05-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60462
Residue number A
83
Residue number B
105
Peptide name
Neuropilin-2
Ligandability
Cysteine 83 of Neuropilin-2
Cysteine 105 of Neuropilin-2
6gh8 C 28 C 55
A redox-regulated disulphide may form within Neuropilin-2 between cysteines 28 and 55.
Details
Redox score ?
85
PDB code
6gh8
Structure name
crystal structure of gp1 domain of lujo virus in complex with the first cub domain of neuropilin-2
Structure deposition date
2018-05-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60462
Residue number A
28
Residue number B
55
Peptide name
Neuropilin-2
Ligandability
Cysteine 28 of Neuropilin-2
Cysteine 55 of Neuropilin-2
4qds A 277 A 427
A redox-regulated disulphide may form within Neuropilin-2 between cysteines 277 and 427.
Details
Redox score ?
83
PDB code
4qds
Structure name
physical basis for nrp2 ligand binding
Structure deposition date
2014-05-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60462
Residue number A
277
Residue number B
427
Peptide name
Neuropilin-2
Ligandability
Cysteine 277 of Neuropilin-2
Cysteine 427 of Neuropilin-2
4qdr A 434 A 592
A redox-regulated disulphide may form within Neuropilin-2 between cysteines 434 and 592.
Details
Redox score ?
82
PDB code
4qdr
Structure name
physical basis for nrp2 ligand binding
Structure deposition date
2014-05-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60462
Residue number A
434
Residue number B
592
Peptide name
Neuropilin-2
Ligandability
Cysteine 434 of Neuropilin-2
Cysteine 592 of Neuropilin-2
7t4s F 149 F 175
A redox-regulated disulphide may form within Neuropilin-2 between cysteines 149 and 175.
Details
Redox score ?
69
PDB code
7t4s
Structure name
cryoem structure of the hcmv pentamer gh/gl/ul128/ul130/ul131a in complex with nrp2 and neutralizing fabs 8i21 and 13h11
Structure deposition date
2021-12-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
nan
Peptide accession
O60462
Residue number A
149
Residue number B
175
Peptide name
Neuropilin-2
Ligandability
Cysteine 149 of Neuropilin-2
Cysteine 175 of Neuropilin-2
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