ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Plexin-C1

Intermolecular
Cysteine 1227 and cysteine 1227
Intramolecular
Cysteine 461 and cysteine 506
Cysteine 801 and cysteine 806
Cysteine 891 and cysteine 907
Cysteine 756 and cysteine 835
Cysteine 475 and cysteine 487
Cysteine 226 and cysteine 354
Cysteine 455 and cysteine 472
Cysteine 412 and cysteine 703
Cysteine 464 and cysteine 481
More...
Cysteine 64 and cysteine 87
Cysteine 734 and cysteine 742
Cysteine 156 and cysteine 194
Cysteine 283 and cysteine 329
Cysteine 455 and cysteine 481
Cysteine 464 and cysteine 472
Cysteine 472 and cysteine 481
Cysteine 455 and cysteine 464
Cysteine 461 and cysteine 481
Cysteine 461 and cysteine 464
Cysteine 481 and cysteine 506
Cysteine 464 and cysteine 506
Cysteine 756 and cysteine 806
Cysteine 806 and cysteine 835
Cysteine 481 and cysteine 487
Cysteine 475 and cysteine 481
Cysteine 464 and cysteine 487
Cysteine 464 and cysteine 475
A redox-regulated disulphide may form between two units of Plexin-C1 at cysteines 1227 and 1227.

Details

Redox score ?
79
PDB code
3kuz
Structure name
crystal structure of the ubiquitin like domain of plxnc1
Structure deposition date
2009-11-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide A name
Plexin-C1
Peptide B name
Plexin-C1
Peptide A accession
O60486
Peptide B accession
O60486
Peptide A residue number
1227
Peptide B residue number
1227

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 461 and 506.

Details

Redox score ?
88
PDB code
3nvq
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
461
Residue number B
506
Peptide name
Plexin-C1

Ligandability

Cysteine 461 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 506 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 801 and 806.

Details

Redox score ?
88
PDB code
6vxk
Structure name
cryo-em structure of the full-length a39r/plexinc1 complex
Structure deposition date
2020-02-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
801
Residue number B
806
Peptide name
Plexin-C1

Ligandability

Cysteine 801 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 806 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 891 and 907.

Details

Redox score ?
87
PDB code
6vxk
Structure name
cryo-em structure of the full-length a39r/plexinc1 complex
Structure deposition date
2020-02-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
891
Residue number B
907
Peptide name
Plexin-C1

Ligandability

Cysteine 891 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 907 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 756 and 835.

Details

Redox score ?
87
PDB code
6vxk
Structure name
cryo-em structure of the full-length a39r/plexinc1 complex
Structure deposition date
2020-02-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
756
Residue number B
835
Peptide name
Plexin-C1

Ligandability

Cysteine 756 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 835 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 475 and 487.

Details

Redox score ?
86
PDB code
3nvq
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
475
Residue number B
487
Peptide name
Plexin-C1

Ligandability

Cysteine 475 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 487 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 226 and 354.

Details

Redox score ?
85
PDB code
3nvn
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
226
Residue number B
354
Peptide name
Plexin-C1

Ligandability

Cysteine 226 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 354 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 455 and 472.

Details

Redox score ?
85
PDB code
3nvq
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
455
Residue number B
472
Peptide name
Plexin-C1

Ligandability

Cysteine 455 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 472 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 412 and 703.

Details

Redox score ?
84
PDB code
6vxk
Structure name
cryo-em structure of the full-length a39r/plexinc1 complex
Structure deposition date
2020-02-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
412
Residue number B
703
Peptide name
Plexin-C1

Ligandability

Cysteine 412 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 703 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 464 and 481.

Details

Redox score ?
84
PDB code
3nvq
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
464
Residue number B
481
Peptide name
Plexin-C1

Ligandability

Cysteine 464 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 481 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 64 and 87.

Details

Redox score ?
84
PDB code
3nvn
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
64
Residue number B
87
Peptide name
Plexin-C1

Ligandability

Cysteine 64 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 87 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 734 and 742.

Details

Redox score ?
82
PDB code
6vxk
Structure name
cryo-em structure of the full-length a39r/plexinc1 complex
Structure deposition date
2020-02-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
734
Residue number B
742
Peptide name
Plexin-C1

Ligandability

Cysteine 734 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 742 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 156 and 194.

Details

Redox score ?
80
PDB code
3nvn
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
156
Residue number B
194
Peptide name
Plexin-C1

Ligandability

Cysteine 156 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 283 and 329.

Details

Redox score ?
78
PDB code
3nvn
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
283
Residue number B
329
Peptide name
Plexin-C1

Ligandability

Cysteine 283 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 329 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 455 and 481.

Details

Redox score ?
65
PDB code
3nvq
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
455
Residue number B
481
Peptide name
Plexin-C1

Ligandability

Cysteine 455 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 481 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 464 and 472.

Details

Redox score ?
65
PDB code
3nvq
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
464
Residue number B
472
Peptide name
Plexin-C1

Ligandability

Cysteine 464 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 472 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 472 and 481.

Details

Redox score ?
62
PDB code
3nvq
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
472
Residue number B
481
Peptide name
Plexin-C1

Ligandability

Cysteine 472 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 481 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 455 and 464.

Details

Redox score ?
61
PDB code
3nvn
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
455
Residue number B
464
Peptide name
Plexin-C1

Ligandability

Cysteine 455 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 464 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 461 and 481. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
3nvq
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
461
Residue number B
481
Peptide name
Plexin-C1

Ligandability

Cysteine 461 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 481 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 461 and 464. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
3nvq
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
461
Residue number B
464
Peptide name
Plexin-C1

Ligandability

Cysteine 461 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 464 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 481 and 506. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
3nvq
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
481
Residue number B
506
Peptide name
Plexin-C1

Ligandability

Cysteine 481 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 506 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 464 and 506. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
3nvq
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
464
Residue number B
506
Peptide name
Plexin-C1

Ligandability

Cysteine 464 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 506 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 756 and 806. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6vxk
Structure name
cryo-em structure of the full-length a39r/plexinc1 complex
Structure deposition date
2020-02-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
756
Residue number B
806
Peptide name
Plexin-C1

Ligandability

Cysteine 756 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 806 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 806 and 835. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6vxk
Structure name
cryo-em structure of the full-length a39r/plexinc1 complex
Structure deposition date
2020-02-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
806
Residue number B
835
Peptide name
Plexin-C1

Ligandability

Cysteine 806 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 835 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 481 and 487. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3nvn
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
481
Residue number B
487
Peptide name
Plexin-C1

Ligandability

Cysteine 481 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 487 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 475 and 481. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3nvq
Structure name
molecular mechanism of guidance cue recognition
Structure deposition date
2010-07-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
475
Residue number B
481
Peptide name
Plexin-C1

Ligandability

Cysteine 475 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 481 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 464 and 487. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6vxk
Structure name
cryo-em structure of the full-length a39r/plexinc1 complex
Structure deposition date
2020-02-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
464
Residue number B
487
Peptide name
Plexin-C1

Ligandability

Cysteine 464 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 487 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-C1 between cysteines 464 and 475. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6vxk
Structure name
cryo-em structure of the full-length a39r/plexinc1 complex
Structure deposition date
2020-02-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60486
Residue number A
464
Residue number B
475
Peptide name
Plexin-C1

Ligandability

Cysteine 464 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 475 of Plexin-C1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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